Optogenetic fMRI Sheds Light on the Neural Basis of the BOLD Signal

被引：6
|
作者：
Palmer, Helen S. [1 ]
机构：
[1] Norwegian Univ Sci & Technol, Fac Med, Dept Circulat & Med Imaging, N-7491 Trondheim, Norway
来源：
JOURNAL OF NEUROPHYSIOLOGY | 2010年 / 104卷 / 04期
关键词：
D O I：
10.1152/jn.00535.2010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used as a measure of neuronal activity, despite an incomplete understanding of the hemodynamic and neural bases for BOLD signals. Recent work by Lee and colleagues investigated whether activating genetically specified neurons elicits BOLD responses. Integrating optogenetic control of specific cells and fMRI showed that stimulating excitatory neurons triggers a positive BOLD signal with conventional kinetics locally and delayed weaker BOLD signals distally.
引用
收藏
页码：1838 / 1840
页数：3
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