Antitumor antibiotics: Bleomycin, endiynes, and mitomycin

被引：474
|
作者：
Galm, U
Hager, MH
Van Lanen, SG
Ju, JH
Thorson, JS
Shen, B [1 ]
机构：
[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA
来源：
CHEMICAL REVIEWS | 2005年 / 105卷 / 02期
关键词：
D O I：
10.1021/cr030117g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.
引用
收藏
页码：739 / 758
页数：20
相关论文
共 50 条
  • [21] Comparative Analysis of the Biosynthetic Gene Clusters and Pathways for Three Structurally Related Antitumor Antibiotics: Bleomycin, Tallysomycin, and Zorbamycin
    Galm, Ute
    Wendt-Pienkowski, Evelyn
    Wang, Liyan
    Huang, Sheng-Xiong
    Unsin, Claudia
    Tao, Meifeng
    Coughlin, Jane M.
    Shen, Ben
    JOURNAL OF NATURAL PRODUCTS, 2011, 74 (03): : 526 - 536
  • [22] A Hybrid NRPS-PKS Gene Cluster Related to the Bleomycin Family of Antitumor Antibiotics in Alteromonas macleodii Strains
    Megumi Mizuno, Carolina
    Kimes, Nikole E.
    Lopez-Perez, Mario
    Auso, Eva
    Rodriguez-Valera, Francisco
    Ghai, Rohit
    PLOS ONE, 2013, 8 (09):
  • [23] Antitumor antibiotics: Duocarmycins
    Nagamura S.
    Saito H.
    Chemistry of Heterocyclic Compounds, 1998, 34 (12) : 1386 - 1405
  • [24] FUNCTIONAL MODELS OF THE ANTITUMOR ANTIBIOTIC BLEOMYCIN
    HUANG, LR
    QUADA, JC
    LOWN, JW
    CURRENT MEDICINAL CHEMISTRY, 1995, 2 (01) : 543 - 560
  • [25] STUDIES ON ANTITUMOR ANTIBIOTICS
    UMEZAWA, H
    TANAKA, N
    NITTA, K
    TAKEUCHI, T
    ACTA UNIO INTERNATIONALIS CONTRA CANCRUM, 1959, 15 (01) : 295 - 296
  • [26] BIOSYNTHESIS OF SOME ANTIBIOTICS (INDOLMYCIN, MITOMYCIN)
    FLOSS, H
    ARCHIV DER PHARMAZIE UND BERICHTE DER DEUTSCHEN PHARMAZEUTISCHEN GESSELSCHAFT, 1969, 302 (12): : B284 - &
  • [27] ANTITUMOR ACTIVITY OF BLEOMYCIN A2
    BRADNER, WT
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1970, 11 : 11 - &
  • [28] Antitumor antibiotics: Duocarmycins
    Nagamura, S
    Saito, H
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1998, (12): : 1636 - 1657
  • [29] ACTINOMYCIN AND ANTITUMOR ANTIBIOTICS
    YOUNG, CW
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1969, 52 (02) : 130 - +
  • [30] POTENTIATION OF BLEOMYCIN ANTITUMOR EFFECTIVENESS BY ELECTROTHERAPY
    SERSA, G
    NOVAKOVIC, S
    MIKLAVCIC, D
    CANCER LETTERS, 1993, 69 (02) : 81 - 84
12345