Antitumor antibiotics: Bleomycin, endiynes, and mitomycin

被引：474
|
作者：
Galm, U
Hager, MH
Van Lanen, SG
Ju, JH
Thorson, JS
Shen, B [1 ]
机构：
[1] Univ Wisconsin, Div Pharmaceut Sci, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Chem, Madison, WI 53705 USA
来源：
CHEMICAL REVIEWS | 2005年 / 105卷 / 02期
关键词：
D O I：
10.1021/cr030117g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Natural-product-derived cytotoxics are still widely used in chemotherapy. A review is given of the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and 10-membered enediynes, and mitomycins. A comparison of resistance mechanisms within producing organisms and those predominant among tumor cells reveals potential for continued development of these essential anticancer agents.
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页码：739 / 758
页数：20
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