Is ghrelin a biomarker for mortality in end-stage renal disease?

被引：20
|
作者：
Mak, Robert H. [1 ]
Cheung, Wai W. [1 ]
机构：
[1] Univ Calif San Diego, Div Pediat Nephrol, Rady Childrens Hosp, San Diego, CA 92103 USA
来源：
KIDNEY INTERNATIONAL | 2011年 / 79卷 / 07期
关键词：
D O I：
10.1038/ki.2010.520
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin is involved in the pathogenesis of protein-energy wasting (PEW), inflammation, and cardiovascular complications in end-stage renal disease (ESRD). Plasma ghrelin may prove to be a powerful biomarker of mortality in ESRD but should be considered in the context of assay specificity, other weight-regulating hormones, nutritional status, systemic inflammation, and cardiovascular risk factors. ESRD patients with PEW, systemic inflammation, and low ghrelin and high leptin concentrations have the highest mortality risk and may benefit the most from ghrelin therapy. Kidney International (2011) 79, 697-699. doi: 10.1038/ki.2010.520
引用
收藏
页码：697 / 699
页数：3
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