Multicellular dynamics of zonal liver regeneration mapped in space and time

被引：2

作者：

Chen, Feng ^{[1
]}

Tchorz, Jan S. ^{[2
]}

机构：

[1] Novartis Pharma AG, Novartis Inst BioMed Res, Cambridge, MA USA

[2] Novartis Pharma AG, Novartis Inst BioMed Res, Basel, Switzerland

来源：

CELL STEM CELL | 2022年 / 29卷 / 06期

关键词：

resolved single-cell sequencing (scRNA-; went transient fetal reprogramming; HOMEOSTASIS;

D O I：

10.1016/j.stem.2022.05.008

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.

引用

页码：871 / 872

页数：2

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