Multicellular dynamics of zonal liver regeneration mapped in space and time

被引：2
|
作者：
Chen, Feng [1 ]
Tchorz, Jan S. [2 ]
机构：
[1] Novartis Pharma AG, Novartis Inst BioMed Res, Cambridge, MA USA
[2] Novartis Pharma AG, Novartis Inst BioMed Res, Basel, Switzerland
来源：
CELL STEM CELL | 2022年 / 29卷 / 06期
关键词：
resolved single-cell sequencing (scRNA-; went transient fetal reprogramming; HOMEOSTASIS;
D O I：
10.1016/j.stem.2022.05.008
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.
引用
收藏
页码：871 / 872
页数：2
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