Evolution to malignancy in a recurrent meningioma: morphological and cytogenetic findings

被引：0
|
作者：
Cerda-Nicolas, N
Lopez-Gines, C
Barcia-Salorio, J
Llombart-Bosch, A
机构：
[1] Univ Valencia, Dept Pathol, E-46003 Valencia, Spain
[2] Univ Valencia, Dept Surg Neurosurg, E-46003 Valencia, Spain
来源：
CLINICAL NEUROPATHOLOGY | 1998年 / 17卷 / 04期
关键词：
recurrent meningioma; PCNA-LI; micronecrosis; karyotype;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The original tumor and 4 relapses of a recurrent meningioma were studied. We analyzed and compared these recurrences by histopathology, PCNA labelling index (PCNA-LI), nuclear count, and cytogenetical findings. The most important changes in the evolution to aggressivity were: recurrences at progressively shorter intervals, increases in the PCNA-LI, and micronecrosis; histological changes such as sheeting and increase of the extracellular matrix and a gradual transformation to a clonally complex karyotype.
引用
收藏
页码：210 / 215
页数：6
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