Development of MK-4827: A novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and-2 mutant tumors

被引:0
|
作者
Jones, Philip [1 ]
Altamura, Sergio [1 ]
Boueres, Julia [1 ]
Ferrigno, Federica [1 ]
Fonsi, Massimiliano [1 ]
Gavory, Gerald [1 ]
Giomini, Claudia [1 ]
Koch, Uwe [1 ]
Lamartina, Stefania [1 ]
Monteagudo, Edith [1 ]
Ontoria, Jesus M. [1 ]
Roscilli, Giuseppe [1 ]
Rowley, Michael [1 ]
Scarpelli, Rita [1 ]
Schultz-Fademrecht, Carsten [1 ]
Toniatti, Carlo [1 ]
机构
[1] IRBM Merck Res Labs Rome, I-00040 Pomezia, Italy
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
220-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [31] BRCA1/2 Reversion Mutations in Patients Treated with Poly ADP-Ribose Polymerase (PARP) Inhibitors or Platinum Agents
    Darabi, Sourat
    Braxton, David R. R.
    Xiu, Joanne
    Carneiro, Benedito A. A.
    Swensen, Jeff
    Antonarakis, Emmanuel S. S.
    Liu, Stephen V. V.
    McKay, Rana R. R.
    Spetzler, David
    El-Deiry, Wafik S. S.
    Demeure, Michael J. J.
    MEDICINA-LITHUANIA, 2022, 58 (12):
  • [32] Distribution of pamiparib, a novel inhibitor of poly(ADP-ribose)-polymerase (PARP), in tumor tissue analyzed by multimodal imaging
    Morosi, Lavinia
    Timo, Sara
    Amodeo, Rosy
    Lupi, Monica
    Meroni, Marina
    Bello, Ezia
    Frapolli, Roberta
    Martano, Giuseppe
    D'Incalci, Maurizio
    JOURNAL OF PHARMACEUTICAL ANALYSIS, 2025, 15 (03)
  • [33] A novel crosstalk between BRCA1 and poly (ADP-ribose) polymerase 1 in breast cancer
    Li, Da
    Bi, Fang-Fang
    Chen, Na-Na
    Cao, Ji-Min
    Sun, Wu-Ping
    Zhou, Yi-Ming
    Li, Chun-Yan
    Yang, Qing
    CELL CYCLE, 2014, 13 (21) : 3442 - 3449
  • [34] Efficacy and safety of oral poly (ADP-ribose) polymerase inhibitor fluzoparib in patients with BRCA1/2 mutations and recurrent ovarian cancer
    Li, N.
    Bu, H.
    Liu, J.
    Zhu, J.
    Zhou, Q.
    Wang, L.
    Yin, R.
    Wu, X.
    Yao, S.
    Gu, K.
    Zhang, H.
    Li, G.
    Pan, H.
    Wu, Q.
    An, R.
    Yang, X.
    Zhu, Y.
    Wan, X.
    Duan, W.
    Xiong, J.
    Wang, Y.
    Wang, Q.
    Zou, J.
    Wu, L. Y.
    GYNECOLOGIC ONCOLOGY, 2020, 159 : 159 - 159
  • [35] MEDI 479-Discovery and SAR of highly potent, orally efficacious inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer
    Zhu, Gui-Dong
    Gong, Jianchun
    Gandhi, Viraj B.
    Thomas, Sheela
    Luo, Yan
    Liu, Xuesong
    Shi, Yan
    Klinghofer, Vered
    Johnson, Eric F.
    Frost, David
    Donawho, Cherrie
    Osterling, Donald
    Rodriguez, Luis
    Bukofzer, Gail
    Bouska, Jennifer
    Olson, Amanda
    Marsh, Kennan C.
    Rosenberg, Saul H.
    Giranda, Vincent L.
    Penning, Thomas D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [36] Exploration of poly (ADP-ribose) polymerase inhibitor resistance in the treatment of BRCA1/2-mutated cancer
    Wu, Shuyi
    Yao, Xuanjie
    Sun, Weiwei
    Jiang, Kaitao
    Hao, Jie
    GENES CHROMOSOMES & CANCER, 2024, 63 (05):
  • [37] PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
    Amé, JC
    Rolli, V
    Schreiber, V
    Niedergang, C
    Apiou, F
    Decker, P
    Muller, S
    Hoger, T
    Murcia, JMD
    de Murcia, G
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (25) : 17860 - 17868
  • [38] Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
    Yolanda Jerez
    Ivan Márquez-Rodas
    Inmaculada Aparicio
    Manuel Alva
    Miguel Martín
    Sara López-Tarruella
    Drugs, 2020, 80 : 131 - 146
  • [39] Poly (ADP-ribose) Polymerase Inhibition in Patients with Breast Cancer and BRCA 1 and 2 Mutations
    Jerez, Yolanda
    Marquez-Rodas, Ivan
    Aparicio, Inmaculada
    Alva, Manuel
    Martin, Miguel
    Lopez-Tarruella, Sara
    DRUGS, 2020, 80 (02) : 131 - 146
  • [40] Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development
    Wang, Hexiang
    Ren, Bo
    Liu, Ye
    Jiang, Beibei
    Guo, Yin
    Wei, Min
    Luo, Lusong
    Kuang, Xianzhao
    Qiu, Ming
    Lv, Lei
    Xu, Hong
    Qi, Ruipeng
    Yan, Huibin
    Xu, Dexu
    Wang, Zhiwei
    Huo, Chang-Xin
    Zhu, Yutong
    Zhao, Yuan
    Wu, Yiyuan
    Qin, Zhen
    Su, Dan
    Tang, Tristin
    Wang, Fan
    Sun, Xuebing
    Feng, Yingcai
    Peng, Hao
    Wang, Xing
    Gao, Yajuan
    Liu, Yong
    Gong, Wenfeng
    Yu, Fenglong
    Liu, Xuesong
    Wang, Lai
    Zhou, Changyou
    JOURNAL OF MEDICINAL CHEMISTRY, 2020, 63 (24) : 15541 - 15563