Changes of beta-actin mRNA expression in canine vasospastic basilar artery after experimental subarachnoid hemorrhage

被引：24

作者：

Ohkuma, H ^{[1
]}

Tsurutani, H ^{[1
]}

Suzuki, S ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Neurosurg, Hirosaki, Aomori 0368216, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 311卷 / 01期

关键词：

subarachnoid hemorrhage; cerebral vasospasm; vascular remodeling; phenotypic modulation; smooth muscle cell; beta-actin;

D O I：

10.1016/S0304-3940(01)02101-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this study was to investigate whether vascular remodeling occurs during cerebral vasospasm after subarachnoid hemorrhage (SAH). Beta-actin mRNA expression and structural change of its 3 ' untranslated region (UTR) which are considered a non-specific marker for vascular remodeling, were examined by Northern analysis and polymerase chain reaction analysis in a canine basilar artery after experimental SAH. The changes in the area of tunica media in the basilar artery were also examined histopathologically. Increased beta-actin mRNA expression and its structural changes of 3 ' UTR in the vasospastic basilar artery were markedly seen 7 and 14 days after SAH accompanied by increased area of tunica media in the basilar artery. The results suggest that vascular remodeling occurs and takes part in the luminal narrowing during cerebral vasospasm. (C) 2001 Elsevier Science Inc.. All rights reserved.

引用

页码：9 / 12

页数：4

共 50 条

[31] EFFECT OF NICARDIPINE ON BASILAR ARTERY VASOACTIVE RESPONSES AFTER SUBARACHNOID HEMORRHAGE
PASQUALIN, A
TSUKAHARA, T
KASSELL, NF
TORNER, JC
PICKARD, JD
NEUROSURGERY, 1992, 31 (04) : 697 - 704
[32] Comparison of three measurement methods for basilar artery with neurological changes in rabbits subjected to experimental subarachnoid hemorrhage
Kuo, J. R.
Yen, C. P.
Wu, S. C.
Su, Y. F.
Howng, S. L.
Kwan, A. L.
Jeng, A. Y.
Winardi, W.
Kassell, N. F.
Chang, C. Z.
CEREBRAL VASOSPASM: NEW STRATEGIES IN RESEARCH AND TREATMENT, 2008, 104 : 203 - +
[33] THE EFFECT OF NICARDIPINE ON VASOSPASM IN RABBIT BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE
PASQUALIN, A
VOLLMER, DG
MARRON, JA
TSUKAHARA, T
KASSELL, NF
TORNER, JC
NEUROSURGERY, 1991, 29 (02) : 183 - 188
[34] ALTERATIONS OF MECHANICAL-PROPERTIES IN CANINE BASILAR ARTERIES AFTER SUBARACHNOID HEMORRHAGE
KIM, P
SUNDT, TM
VANHOUTTE, PM
JOURNAL OF NEUROSURGERY, 1989, 71 (03) : 430 - 436
[35] PROTEIN-KINASE ACTIVITY IN CANINE BASILAR ARTERIES AFTER SUBARACHNOID HEMORRHAGE
SUZUKI, Y
SHIBUYA, M
TAKAYASU, M
ASANO, T
IKEGAKI, I
SATOH, S
SAITO, M
HIDAKA, H
NEUROSURGERY, 1988, 22 (06) : 1028 - 1031
[36] SELECTIVE ALTERATION OF DILATOR RESPONSES OF THE BASILAR ARTERY AFTER SUBARACHNOID HEMORRHAGE
SOBEY, CG
HEISTAD, DD
FARACI, FM
HYPERTENSION, 1995, 26 (03) : 568 - 568
[37] Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits
Volker Neuschmelting
Ali-Reza Fathi
Eveline Teresa Hidalgo Staub
Serge Marbacher
Gerhard Schroth
Jukka Takala
Stephan M. Jakob
Javier Fandino
Acta Neurochirurgica, 2009, 151 : 487 - 493
[38] Norepinephrine-induced hypertension dilates vasospastic basilar artery after subarachnoid haemorrhage in rabbits
Neuschmelting, Volker
Fathi, Ali-Reza
Staub, Eveline Teresa Hidalgo
Marbacher, Serge
Schroth, Gerhard
Takala, Jukka
Jakob, Stephan M.
Fandino, Javier
ACTA NEUROCHIRURGICA, 2009, 151 (05) : 487 - 493
[39] CHANGES IN EXPRESSION OF BETA-ACTIN DURING MOUSE SKIN TUMOR PROGRESSION
OSTROWSKI, LE
KRIEG, P
FINCH, J
BOWDEN, GT
PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1988, 29 : 140 - 140
[40] Intimal Hemorrhage of Basilar Artery Induced by Severe Vasospasm Following Subarachnoid Hemorrhage: The Experimental Analysis
Gokyar, Ahmet
Sahin, Mehmet Hakan
Karadag, Mehmet Kursat
Bahadir, Sinan
Zeynal, Mete
Sipal, Sare Altas
Aydin, Mehmet D.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY, 2024,

← 1 2 3 4 5 →