Biomimetic properties of an injectable chitosan/nano-hydroxyapatite/collagen composite

被引：71
|
作者：
Huang, Zhi [1 ]
Feng, Qingling [1 ]
Yu, Bo [2 ]
Li, Songjian [2 ]
机构：
[1] Tsinghua Univ, Dept Mat Sci & Engn, Adv Mat Lab, Beijing 100084, Peoples R China
[2] So Med Univ, Zhujiang Hosp, Dept Orthoped, Guangzhou 510282, Guangdong, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2011年 / 31卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Biomimetic; Injectable; Hydrogel; In situ; Bone; STEM-CELL DIFFERENTIATION; BONE; HYDROGELS; SCAFFOLD; CALCIUM; MICROSTRUCTURE; BIOMATERIALS; DEGRADATION; TIME; XPS;
D O I：
10.1016/j.msec.2010.12.014
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
To meet the challenges of designing an injectable scaffold and regenerating bone with complex three-dimensional (3D) structures, a biomimetic and injectable hydrogel scaffold based on nano-hydroxyapatite (HA), collagen (Col) and chitosan (Chi) is synthesized. The chitosan/nano-hydroxyapatite/collagen (Chi/HA/Col) solution rapidly forms a stable gel at body temperature. It shows some features of natural bone both in main composition and microstructure. The Chi/HA/Col system can be expected as a candidate for workable systemic minimally invasive scaffolds with surface properties similar to physiological bone based on scanning electron microscopic (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS). X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) results. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：683 / 687
页数：5
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