Design and Implementation of a Transmit/Receive Ultrasound Phased Array for Brain Applications

被引:22
|
作者
Liu, Hao-Li [1 ,2 ]
Tsai, Chih-Hung [1 ,2 ]
Jan, Chen-Kai [1 ,2 ]
Chang, Hsin-Yu [1 ,2 ]
Huang, Sheng-Min [3 ]
Li, Meng-Lin [3 ]
Qiu, Weibao [4 ]
Zheng, Hairong [4 ]
机构
[1] Chang Gung Univ, Dept Elect Engn, Taoyuan 333, Taiwan
[2] Chang Gung Mem Hosp, Dept Neurosurg, Taoyuan 333, Taiwan
[3] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 300, Taiwan
[4] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Hlth Engn, Paul C Lauterbur Res Ctr Biomed Imaging, Shenzhen 518055, Peoples R China
关键词
Blood-brain barrier (BBB) opening; coherent beam formation; dual transmit/receive mode; transcranial brain therapy; ultrasound phased array; TRANSCRANIAL FOCUSED ULTRASOUND; ACOUSTIC CAVITATION PROBABILITIES; MODE ULTRASOUND; BARRIER DISRUPTION; HUMAN SKULL; MRI; DELIVERY; THERAPY; SURGERY; SYSTEM;
D O I
10.1109/TUFFC.2018.2855181
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Focused ultrasound phased array systems have attracted increased attention for brain therapy applications. However, such systems currently lack a direct and real-time method to intraoperatively monitor ultrasound pressure distribution for securing treatment. This study proposes a dual-mode ultrasound phased array system design to support transmit/receive operations for concurrent ultrasound exposure and backscattered focal beam reconstruction through a spherically focused ultrasound array. A 256-channel ultrasound transmission system was used to transmit focused ultrasonic energy (full 256 channels), with an extended implementation of multiple-channel receiving function (up to 64 channels) using the same 256-channel ultrasound array. A coherent backscatter-received beam formation algorithm was implemented to map the point spread function (PSF) and focal beam distribution under a free-field/transcranial environment setup, with the backscattering generated from a strong scatterer (a point reflector or a microbubble-perfused tube) or a weakly scattered tissue-mimicking graphite phantom. Our results showed that PSF and focal beam can be successfully reconstructed and visualized in free-field conditions and can also be transcranially reconstructed following skull-induced aberration correction. In vivo experiments were conducted to demonstrate its capability to preoperatively and semiquantitatively map a focal beam to guide blood-brain barrier opening. The proposed system may have potential for real-time guidance of ultrasound brain intervention, and may facilitate the design of a dual-mode ultrasound phased array for brain therapeutic applications.
引用
收藏
页码:1756 / 1767
页数:12
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