A three-component solid-phase synthesis of 3-aminoimidazo[1,2-a]azines

被引：125
|
作者：
Blackburn, C [1 ]
机构：
[1] Millennium Pharmaceut, Drug Discovery, Cambridge, MA 02139 USA
来源：
TETRAHEDRON LETTERS | 1998年 / 39卷 / 31期
关键词：
D O I：
10.1016/S0040-4039(98)01113-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The three-component condensation between a 2-aminoazine, an aldehyde and an isonitrile catalyzed by scandium triflate was conducted on a solid support with any of the three reacting functional groups tethered to Rink amide resin via an appropriate bifunctional carboxylic acid. The resulting resin-bound 3-aminoimidazo[1,2-a]azines could be efficiently acylated prior to cleavage. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：5469 / 5472
页数：4
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