A chiral cyclohexanone linked to polystyrene for solid-phase synthesis of chiral α-carbonyls

被引：9

作者：

Spino, C ^{[1
]}

Gund, VG ^{[1
]}

Nadeau, C ^{[1
]}

机构：

[1] Univ Sherbrooke, Dept Chim, Sherbrooke, PQ J1K 2R1, Canada

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1021/cc049859t

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two chiral cyclohexanones were linked to polystyrene resin. The polymer-bound auxiliaries were subjected to a sequence of four reactions, the last of which cleaves the desired alpha-chiral carbonyl compound off the resin, concurrently regenerating the resin-bound auxiliary in its original form. The resin can then be reused.

引用

页码：345 / 352

页数：8

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