The synergy between ionizing radiation and immunotherapy in the treatment of prostate cancer

被引：2
|
作者：
Sathianathen, Niranjan J. [1 ]
Krishna, Suprita [1 ]
Konety, Badrinath R. [1 ,2 ]
Griffith, Thomas S. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Minnesota, Dept Urol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Ctr Immunol, Minneapolis, MN 55455 USA
[4] Univ Minnesota, Microbiol Immunol & Canc Biol Grad Program, Minneapolis, MN 55455 USA
来源：
IMMUNOTHERAPY | 2017年 / 9卷 / 12期
关键词：
checkpoint inhibitors; combination therapy; immunotherapy; prostate; radiotherapy; CD8(+) T-CELLS; CLASS-I EXPRESSION; PHASE-III TRIAL; GUT MICROBIOTA; ANTITUMOR IMMUNITY; DEFINITIVE RADIOTHERAPY; TUMOR MICROENVIRONMENT; RADIOLIGAND THERAPY; BODY IRRADIATION; CTLA-4; BLOCKADE;
D O I：
10.2217/imt-2017-0051
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
There has been a surge in the use of immunotherapy for genitourinary malignancies. Immunotherapy is an established treatment for metastatic renal cell carcinoma and nonmuscle invasive bladder cancer, but its potential for treating prostate cancer (PCa) remains under investigation. Despite reported survival benefits, no published Phase III PCa trials using immunotherapy only as a treatment has demonstrated direct antitumor effects by reducing prostate-specific antigen levels. Subsequently, the thought of combining immunotherapy with other treatment modalities has gained traction as a way to achieving optimal results. Based on data from other malignancies, it is hypothesized that radiotherapy and immunotherapy can act synergistically to improve outcomes. We will discuss the clinical potential of combining immune-based treatments with radiotherapy as a treatment for advanced PCa.
引用
收藏
页码：1005 / 1018
页数：14
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