Pd-Catalyzed Carbonylative Synthesis of 4H-Benzo[d][1,3]Oxazin-4-Ones Using Benzene-1,3,5-Triyl Triformate as the CO Source

被引：5

作者：

Zheng, Yan ^{[1
]}

Dong, Mengke ^{[1
]}

Qu, Erdong ^{[1
]}

Bai, Jin ^{[1
]}

Wu, Xiao-Feng ^{[2
,3
]}

Li, Wanfang ^{[1
]}

机构：

[1] Univ Shanghai Sci & Technol, Sch Mat & Chem, Shanghai 200093, Peoples R China

[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Liaoning, Peoples R China

[3] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2021年 / 27卷 / 65期

基金：

中国国家自然科学基金;

关键词：

benzoxazinone; carbonylation; heterocycles; palladium; synthetic methods; MOLECULAR REARRANGEMENT; OXIDATIVE CYCLIZATION; POLYPHOSPHORIC ACID; ANTHRANILIC ACID; ARYL; BENZOXAZINONES; FORMATE; BOND; CYCLOCARBONYLATION; DERIVATIVES;

D O I：

10.1002/chem.202103137

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile synthesis of 4H-benzo[d][1,3]oxazin-4-one derivatives by Pd-catalyzed carbonylative cross-coupling between N-(ortho-bromoaryl)amides and benzene-1,3,5-triyl triformate (TFBen) was developed. This procedure does not require the toxic and flammable gas CO as the carbonyl source and tolerates a wide scope of functional groups. Remarkably, 4H-benzo[d][1,3]oxazin-4-ones incorporated to natural products and drugs can be constructed by this method.

引用

页码：16219 / 16224

页数：6

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