FTO: linking m6A demethylation to adipogenesis

被引：80

作者：

Ben-Haim, Moshe Shay ^{[1
,2
]}

Moshitch-Moshkovitz, Sharon ^{[1
]}

Rechavi, Gideon ^{[1
,2
]}

机构：

[1] Chaim Sheba Med Ctr, Sheba Canc Res Ctr, IL-52621 Tel Hashomer, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

CELL RESEARCH | 2015年 / 25卷 / 01期

关键词：

GENE; RNA; N6-METHYLADENOSINE; MASS;

D O I：

10.1038/cr.2014.162

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Polymorphism of the FTO gene encoding an N6-methyladenosine (m6A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

引用

页码：3 / 4

页数：2

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