FTO: linking m6A demethylation to adipogenesis

被引：80
|
作者：
Ben-Haim, Moshe Shay [1 ,2 ]
Moshitch-Moshkovitz, Sharon [1 ]
Rechavi, Gideon [1 ,2 ]
机构：
[1] Chaim Sheba Med Ctr, Sheba Canc Res Ctr, IL-52621 Tel Hashomer, Israel
[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
来源：
CELL RESEARCH | 2015年 / 25卷 / 01期
关键词：
GENE; RNA; N6-METHYLADENOSINE; MASS;
D O I：
10.1038/cr.2014.162
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Polymorphism of the FTO gene encoding an N6-methyladenosine (m6A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.
引用
收藏
页码：3 / 4
页数：2
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