Ceramicines E-I, New Limonoids from Chisocheton ceramicus

被引：28

作者：

Wong, Chin Piow ^{[1
]}

Shimada, Misae ^{[1
]}

Nagakura, Yuta ^{[1
]}

Nugroho, Alfarius Eko ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Kaneda, Toshio ^{[1
]}

Awang, Khalijah ^{[2
]}

Hadi, A. Hamid A. ^{[2
]}

Mohamad, Khalit ^{[3
]}

Shiro, Motoo ^{[4
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Univ Malaya, Fac Sci, Dept Chem, Kuala Lumpur 50603, Malaysia

[3] Univ Malaya, Fac Med, Dept Pharm, Kuala Lumpur 50603, Malaysia

[4] Rigaku Corp, Xray Res Lab, Tokyo 1968666, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 03期

关键词：

limonoid; Chisocheton ceramicus; ceramicine; cytotoxic activity; MELIACEAE; PLANTS;

D O I：

10.1248/cpb.59.407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new limonoids, ceramicines E-I (1-5), have been isolated from the bark of Chisocheton ceramicus. The structures and relative stereochemistry of them were fully elucidated based on 1D- and 2D-NMR data. Ceramicines E-I (1-5) exhibited moderate cell growth inhibitory activities on a range of cell lines (HL-60, A549, MCF7, and HCT116). The absolute structure of previously isolated ceramicine B (6) was also elucidated by circular dichroism (CD) and X-ray analysis.

引用

页码：407 / 411

页数：5

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