Tumor necrosis factor alpha plays a role in the acceleration of atherosclerosis by Chlamydia pneumoniae in mice

被引：20

作者：

Campbell, LA ^{[1
]}

Nosaka, T ^{[1
]}

Rosenfeld, ME ^{[1
]}

Yaraei, K ^{[1
]}

Kuo, CC ^{[1
]}

机构：

[1] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 05期

关键词：

D O I：

10.1128/IAI.73.5.3164-3165.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of tumor necrosis factor alpha (TNF-alpha) in Chlamydia pneumoniae atherogenesis was evaluated in TNF-alpha p55 receptor-deficient C57BL/6J mice fed a high-fat/high-cholesterol diet. No acceleration of atherosclerotic lesion development was observed in infected mice compared to uninfected mice, indicating that TNF-alpha plays a role in the acceleration of atherosclerosis by C. pneumoniae.

引用

页码：3164 / 3165

页数：2

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