Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

被引：50

作者：

Verdoes, Martijn ^{[1
]}

Hillaert, Ulrik ^{[1
]}

Florea, Bogdan I. ^{[1
]}

Sae-Heng, Myra ^{[1
]}

Risseeuw, Martijn D. P. ^{[1
]}

Filippov, Dmitri V. ^{[1
]}

van der Marel, Gijsbert A. ^{[1
]}

Overkleeft, Herman S. ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期

关键词：

fluorophore; proteasome; inhibitor; bioconjugate;

D O I：

10.1016/j.bmcl.2007.09.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6169 / 6171

页数：3

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