Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

被引：50
|
作者：
Verdoes, Martijn [1 ]
Hillaert, Ulrik [1 ]
Florea, Bogdan I. [1 ]
Sae-Heng, Myra [1 ]
Risseeuw, Martijn D. P. [1 ]
Filippov, Dmitri V. [1 ]
van der Marel, Gijsbert A. [1 ]
Overkleeft, Herman S. [1 ]
机构：
[1] Leiden Univ, Leiden Inst Chem, NL-2300 RA Leiden, Netherlands
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 22期
关键词：
fluorophore; proteasome; inhibitor; bioconjugate;
D O I：
10.1016/j.bmcl.2007.09.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6169 / 6171
页数：3
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