A mathematical model for the secondary drying of a freeze-drying process

被引：1
|
作者：
Font, F. [1 ,2 ]
Lee, W. [1 ,2 ]
机构：
[1] Univ Limerick, Pharmaceut Mfg Technol Ctr, Limerick, Ireland
[2] Univ Limerick, Dept Math & Stat, MACSI, Limerick, Ireland
来源：
4TH INTERNATIONAL CONFERENCE ON MATHEMATICAL MODELING IN PHYSICAL SCIENCES (IC-MSQUARE2015) | 2015年 / 633卷
关键词：
TRANSPORT;
D O I：
10.1088/1742-6596/633/1/012060
中图分类号：
O1 [数学];
学科分类号：
0701 ; 070101 ;
摘要：
In this manuscript a mathematical model describing the secondary drying stage of a freeze-drying process is presented. The model consists in governing equations for the transport of an air-vapour mixture in a porous medium. The production of water vapour due to the desorption of bound water is accounted for by means of a source term in the equation for the water vapour concentration. We show how, in the limit of small Peclet numbers, the model can be solved analytically. In addition, we provide with an explicit expression for the total time for the secondary drying stage of the freeze-drying process amenable for real time control applications.
引用
收藏
页数：5
相关论文
共 50 条
  • [21] Exergy analysis for a freeze-drying process
    Liu, Yongzhong
    Zhao, Yanfei
    Feng, Xiao
    APPLIED THERMAL ENGINEERING, 2008, 28 (07) : 675 - 690
  • [22] FREEZE-DRYING PROCESS FOR CERAMIC POWDERS
    不详
    CERAMICS, 1972, 23 (283): : 15 - &
  • [23] DEVELOPMENT OF A FREEZE-DRYING PROCESS FOR FOOD
    WARMAN, KG
    REICHEL, AJ
    CHEMICAL ENGINEER-LONDON, 1970, (238): : C134 - &
  • [24] Process intensification and process control in freeze-drying
    Barresi, A. A.
    Pisano, R.
    IDS'2018: 21ST INTERNATIONAL DRYING SYMPOSIUM, 2018, : 9 - 16
  • [25] Judgment of freeze-drying process based on drying dynamical characteristics
    Cui Q.
    Guo Y.
    Zheng D.
    Nongye Jixie Xuebao/Transactions of the Chinese Society of Agricultural Machinery, 2010, 41 (04): : 124 - 127
  • [26] Simulation Strategies in Mathematical Modeling of Microwave Heating in Freeze-Drying Process
    Witkiewicz, K.
    Nastaj, J. F.
    DRYING TECHNOLOGY, 2010, 28 (08) : 1001 - 1012
  • [27] Microencapsulation of fish oil by spray drying, spray freeze-drying, freeze-drying, and microwave freeze-drying: Microcapsule characterization and storage stability
    Yang, Mengmeng
    Li, Linlin
    Zhu, Xiaomai
    Liang, Luodan
    Chen, Junliang
    Cao, Weiwei
    Liu, Wenchao
    Duan, Xu
    Ren, Guangyue
    Liu, Zhenbin
    JOURNAL OF FOOD SCIENCE, 2024, 89 (06) : 3276 - 3289
  • [28] THE SECONDARY DRYING STAGE OF FREEZE-DRYING - DRYING KINETICS AS A FUNCTION OF TEMPERATURE AND CHAMBER PRESSURE
    PIKAL, MJ
    SHAH, S
    ROY, ML
    PUTMAN, R
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 60 (03) : 203 - 217
  • [29] Beyond freeze-drying of biologics: vacuum-foam drying and spray freeze-drying
    Langford, A.
    Balthazor, B.
    Bhatnagar, B.
    Tchessalov, S.
    Hageman, M. J.
    Lukas, A.
    Plitzko, M.
    Luy, B.
    Ohtake, S.
    IDS'2018: 21ST INTERNATIONAL DRYING SYMPOSIUM, 2018, : 41 - 48
  • [30] FREEZE-DRYING OF PASTES AND HIGHLY VISCOUS LIQUIDS WITH REGARD TO A MORE ECONOMIC OPERATION OF FREEZE-DRYING PROCESS
    SPIESS, WEL
    WOLF, W
    BUTTMI, W
    JUNG, G
    CHEMIE INGENIEUR TECHNIK, 1973, 45 (08) : 498 - 501
12345