Diterpenes from Alomia myriadenia (Asteraceae) with cytotoxic and trypanocidal activity

被引：44

作者：

Scio, E

Ribeiro, A

Alves, TMA

Romanha, AJ

de Souza, JD

Cordell, GA

Zani, CL

机构：

[1] Fiocruz MS, CPqRR, Lab Quim Prod Nat, BR-30190002 Belo Horizonte, MG, Brazil

[2] Univ Fed Juiz de Fora, ICB, Dept Bioquim, BR-36036030 Juiz de Fora, MG, Brazil

[3] Fiocruz MS, CPqRR, Lab Parasitol Celular & Mol, BR-30190002 Belo Horizonte, MG, Brazil

[4] Univ Fed Minas Gerais, ICEx, Dept Quim, Belo Horizonte, MG, Brazil

[5] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

PHYTOCHEMISTRY | 2003年 / 64卷 / 06期

关键词：

Ageratum myriadenium; Alomia myriadenia; Compositae; halimane; labdane; Trypanosoma cruzi; human cancer cell line;

D O I：

10.1016/S0031-9422(03)00529-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Further investigation of the aerial parts of Alomia myriadenia revealed an halimane diterpene identified as ent-8S,12S-epoxy-7R,16-dihydroxyhalima-5(10),13-dien-15,16-olide along with the known ent-16-hydroxylabda-7,13-dien-15,16-olide, ent-12Rhydroxylabda-7,13-dien-15,16-olide, 6,7-methylenedioxycoumarin (ayapin), and kaempferol-7-methylether (rhamnocitrin). Evaluated in a panel of human cancer cell lines, the 16-hydroxylabade diterpene was the most active, showing an ED50 value of 0.3 mug/ml against Lu1 (human lung cancer) cells. Tested in vitro against Trypanosoma cruzi in infected murine blood, this compound caused lysis of 100% of the parasites at 250 mug/ml. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1125 / 1131

页数：7

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