NO-independent stimulators of soluble guanylate cyclase

被引：132
|
作者：
Straub, A
Stasch, JP
Alonso-Alija, C
Benet-Buchholz, J
Ducke, B
Feurer, A
Fürstner, C
机构：
[1] Bayer AG, Ctr Agr, Pharma Res Ctr, Inst Med Chem, D-40789 Monheim, Germany
[2] Bayer AG, Pharma Res Ctr, Inst Cardiovasc & Arteriosclerosis Res, D-40789 Monheim, Germany
[3] Bayer AG, Div Struct Res, Cent Res, Xray Lab, D-51368 Leverkusen, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(01)00073-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
SARs around a novel type of guanylate cyclase stimulator which act by a mechanism different from classical NO-donors are described. Several pyrazolopyridinylpyrimidines are shown to relax aortic rings and revealed a long-lasting blood pressure lowering effect in rats after oral application. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：781 / 784
页数：4
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