Investigation of 1H nuclear magnetic resonance relaxometry to screen metabolic syndrome and diabetes

被引：2

作者：

Jiang, Xiaowen ^{[1
]}

Chen, Yi ^{[1
]}

Wang, Junnan ^{[1
]}

Wu, Zhengxiu ^{[1
]}

Wang, Donglei ^{[2
]}

Qiu, Shanhu ^{[2
]}

Ni, Zhonghua ^{[1
]}

Sun, Zilin ^{[2
]}

Yi, Hong ^{[1
]}

Lu, Rongsheng ^{[1
,3
]}

机构：

[1] Southeast Univ, Jiangsu Key Lab Design & Mfg Micro Nano Biomed In, Nanjing 211189, Peoples R China

[2] Southeast Univ, Zhongda Hosp, Dept Endocrinol, Inst Diabet,Med Sch, Nanjing 211189, Peoples R China

[3] Southeast Univ, State Key Lab Bioelect, Nanjing 211189, Peoples R China

来源：

ANALYTICAL SCIENCES | 2022年 / 38卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Diabetes; Metabolic syndrome; H-1 NMR relaxometry; T-2 and T-1 relaxation time; TIME; HEMOGLOBIN; EXCHANGE; BLOOD;

D O I：

10.1007/s44211-022-00113-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The purpose of this study was to investigate and compare the abilities of H-1 nuclear magnetic resonance (NMR) transverse relaxation constant time (T-2) and longitudinal relaxation constant time (T-1) to screen people at the risk of diabetes and metabolic syndrome. Human blood samples were collected for NMR detection and biochemical examinations. Bivariate correlations, categorical analyses were performed to explore the relationship between NMR relaxation time and metabolic biomarkers. Results show that NMR relaxation time of human serum correlated well with some biomarkers associated with diabetes and metabolic syndrome. Statistically significant differences in NMR relaxation time between subjects with normal and poor metabolic health were observed. NMR relaxation time, especially T-2, can be used to screen people at risk of diabetes and metabolic syndrome.

引用

页码：899 / 905

页数：7

共 50 条

[21] 1H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice
S K Hekmatyar
M Wilson
N Jerome
R M Salek
J L Griffin
A Peet
R A Kauppinen
British Journal of Cancer, 2010, 103 : 1297 - 1304
[22] On the statistics of nuclear magnetic resonance relaxometry
Venkatesh, PK
CHEMICAL PHYSICS, 2001, 272 (2-3) : 149 - 157
[23] Metabolomic Study of Rheumatoid Arthritis Using 1H Nuclear Magnetic Resonance (1H NMR)
Tsezou, Konstantina
Benaki, Dimitra
Iliou, Katerina
Mikros, Emmanuel
Vlachoyiannopoulos, Panayiotis
ARTHRITIS & RHEUMATOLOGY, 2021, 73 : 43 - 46
[24] Water behavior in hybrid silica gels as studied by 1H nuclear magnetic resonance relaxometry. Evidence of two hydration layers
Oulkadi, Djihad
Yemloul, Mehdi
Desobry-Banon, Sylvie
Canet, Daniel
MICROPOROUS AND MESOPOROUS MATERIALS, 2013, 172 : 213 - 216
[25] 1H nuclear magnetic resonance spectroscopic investigation of urine for diagnostic and clinical assessment of methanol intoxication
Janus, T
Borowiak, KS
Pabisiak, K
Machoy-Mokrzynska, A
Swiniarski, A
Rozwadowski, Z
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2005, 97 (04) : 257 - 260
[26] Ligands on Nanocrystal Surfaces, the 1H Nuclear Magnetic Resonance Fingerprint
Hens, Zeger
ACCOUNTS OF CHEMICAL RESEARCH, 2023, 56 (12) : 1623 - 1633
[27] Solution structure of α-conotoxin ImI by 1H nuclear magnetic resonance
Gehrmann, J
Daly, NL
Alewood, PF
Craik, DJ
JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (13) : 2364 - 2372
[28] Determination of residual 1H in reagent by nuclear magnetic resonance spectroscopy
Deng, Xiaojuan
Wang, Yi
Ding, Guosheng
Chinese Journal of Analysis Laboratory, 2023, 42 (01) : 45 - 48
[29] Characterisation of the lipidic components of margarines by 1H Nuclear Magnetic Resonance
Sopelana, P.
Arizabaleta, I.
Ibargoitia, Maria L.
Guillen, Maria D.
FOOD CHEMISTRY, 2013, 141 (04) : 3357 - 3364
[30] 1H Nuclear Magnetic Resonance of a Ferroelectric Liquid Crystalline System
Cha, J. K.
Lee, K. W.
Oh, I. H.
Han, J. H.
Lee, Cheol Eui
Jin, J-I
Choi, J. Y.
JOURNAL OF MAGNETICS, 2010, 15 (02) : 61 - 63

← 1 2 3 4 5 →