Long-lived plasma cells: a mechanism for maintaining persistent antibody production

被引：235
|
作者：
Slifka, MK
Ahmed, R
机构：
[1] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA 92122 USA
[2] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 03期
关键词：
D O I：
10.1016/S0952-7915(98)80162-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Current models suggest that continuous antigenic stimulation of memory B cells is required to maintain long-term antibody production. In view of recent developments concerning plasma cell longevity, a new model is described that incorporates the important role of long-lived plasma cells in sustaining persistent antibody responses.
引用
收藏
页码：252 / 258
页数：7
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