HELP LDL-apheresis in two cases of familial hypercholesterolemic pregnant women

被引：13

作者：

Anedda, Sandra ^{[1
]}

Mura, Silvia ^{[2
]}

Marcello, Costantino ^{[2
]}

Pintus, Paolo ^{[1
]}

机构：

[1] Az Osped G Brotzu, Ctr Metab Dis & Atherosclerosis, Cagliari, Italy

[2] Az Osped G Brotzu, Obstetr & Gynecol Unit, Cagliari, Italy

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 44卷 / 01期

关键词：

Familial Hypercholesterolemia; Autosomic recessive hypercholesterolemia; Pregnancy; Low-density lipoprotein apheresis; Coronary artery disease; DENSITY-LIPOPROTEIN APHERESIS; AUTOSOMAL RECESSIVE HYPERCHOLESTEROLEMIA; OXIDATIVE STRESS; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; PREECLAMPSIA; PRECIPITATION; PATIENT; SIZE;

D O I：

10.1016/j.transci.2010.12.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report our experience with selective LDL-apheresis in two women affected by autosomal recessive hypercholesterolemia and heterozygous familial hypercholesterolemia respectively, during pregnancy. To date only a few cases have been reported, because of the rarity of pregnancy in these patients and a hesitation of physicians to perform extracorporeal treatment. One of the patients had severe coronary artery disease, an absolute contraindication for pregnancy. Both patients had extremely elevated lipoprotein values because of their primary dyslipidemia, pregnancy-related modification of their lipid profile, and mandatory discontinuation of lipid-lowering drugs. In both cases the use of the Heparin-induced Extracorporeal Lipoprotein Precipitation (HELP) therapy improved the clinical situation and resulted in a good outcome for both mother and fetus. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：21 / 24

页数：4

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