Biological Basis of Depression in Adults with Diabetes

被引：147

作者：

Champaneri, Shivam ^{[2
]}

Wand, Gary S. ^{[2
,3
]}

Malhotra, Saurabh S. ^{[4
]}

Casagrande, Sarah S. ^{[2
]}

Golden, Sherita Hill ^{[1
]}

机构：

[1] Johns Hopkins Univ, Div Endocrinol & Metab, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Psychiat, Sch Med, Baltimore, MD 21205 USA

[4] Indiana Univ, Dept Med, Indianapolis, IN USA

来源：

CURRENT DIABETES REPORTS | 2010年 / 10卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Diabetes; Depression; Type; 2; diabetes; Obesity; Metabolic syndrome; Hypothalamic-pituitary-adrenal (HPA) axis; Sympathetic nervous system; Cortisol; Catecholamines; Inflammation; Inflammatory markers; Cytokines; Insulin resistance; Cortisol awakening response; Diurnal cortisol; Awakening cortisol; Visceral fat; Heart rate variability; Adipocytokines; C-reactive protein (CRP); Interleukin-6 (IL-6); CORTISOL AWAKENING RESPONSE; POST-PUBERTAL ADOLESCENTS; AUTONOMIC NERVOUS-SYSTEM; HEART-RATE-VARIABILITY; ADRENAL-GLAND VOLUME; METABOLIC SYNDROME; INFLAMMATORY BIOMARKERS; PSYCHOLOGICAL STRESS; INSULIN SENSITIVITY; OXIDATIVE STRESS;

D O I：

10.1007/s11892-010-0148-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.

引用

页码：396 / 405

页数：10

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