The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities

被引：98
|
作者：
Raskova, Magdalena [1 ,2 ]
Lacina, Lukas [3 ,4 ,5 ,6 ]
Kejik, Zdenek [3 ,4 ,7 ]
Venhauerova, Anna [2 ]
Skalickova, Marketa [2 ]
Kolai, Michal [3 ,8 ]
Jakubek, Milan [3 ,4 ,7 ]
Rosel, Daniel [1 ,2 ]
Smetana, Karel Jr Jr [3 ,4 ,6 ]
Brabek, Jan [1 ,2 ]
机构：
[1] Charles Univ Prague, Fac Sci, Dept Cell Biol, Prague 12000, Czech Republic
[2] Charles Univ Prague, Fac Sci, BIOCEV, Vestec 25250, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Ctr Tumour Ecol, Prague 12000, Czech Republic
[4] Charles Univ Prague, Fac Med 1, BIOCEV, Vestec 25250, Czech Republic
[5] Charles Univ Prague, Fac Med 1, Inst Anat, Prague 12000, Czech Republic
[6] Charles Univ Prague, Fac Med 1, Dept Dermatovenereol, Prague 12000, Czech Republic
[7] Gen Univ Hosp, Prague 12000, Czech Republic
[8] Czech Acad Sci, Inst Mol Genet, Lab Genom & Bioinformat, Prague 14000, Czech Republic
来源：
CELLS | 2022年 / 11卷 / 22期
关键词：
IL-6; cancer; metastasis; STAT3; INHIBITOR; PHASE-I; NONPEPTIDE ANTAGONIST; MITOCHONDRIAL STAT3; SIGNALING PATHWAY; TRANSCRIPTION; MADINDOLINE-A; INTERLEUKIN-6; INVASION; GROWTH;
D O I：
10.3390/cells11223698
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
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收藏
页数：23
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