The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities

被引：98

作者：

Raskova, Magdalena ^{[1
,2
]}

Lacina, Lukas ^{[3
,4
,5
,6
]}

Kejik, Zdenek ^{[3
,4
,7
]}

Venhauerova, Anna ^{[2
]}

Skalickova, Marketa ^{[2
]}

Kolai, Michal ^{[3
,8
]}

Jakubek, Milan ^{[3
,4
,7
]}

Rosel, Daniel ^{[1
,2
]}

Smetana, Karel Jr Jr ^{[3
,4
,6
]}

Brabek, Jan ^{[1
,2
]}

机构：

[1] Charles Univ Prague, Fac Sci, Dept Cell Biol, Prague 12000, Czech Republic

[2] Charles Univ Prague, Fac Sci, BIOCEV, Vestec 25250, Czech Republic

[3] Charles Univ Prague, Fac Med 1, Ctr Tumour Ecol, Prague 12000, Czech Republic

[4] Charles Univ Prague, Fac Med 1, BIOCEV, Vestec 25250, Czech Republic

[5] Charles Univ Prague, Fac Med 1, Inst Anat, Prague 12000, Czech Republic

[6] Charles Univ Prague, Fac Med 1, Dept Dermatovenereol, Prague 12000, Czech Republic

[7] Gen Univ Hosp, Prague 12000, Czech Republic

[8] Czech Acad Sci, Inst Mol Genet, Lab Genom & Bioinformat, Prague 14000, Czech Republic

来源：

CELLS | 2022年 / 11卷 / 22期

关键词：

IL-6; cancer; metastasis; STAT3; INHIBITOR; PHASE-I; NONPEPTIDE ANTAGONIST; MITOCHONDRIAL STAT3; SIGNALING PATHWAY; TRANSCRIPTION; MADINDOLINE-A; INTERLEUKIN-6; INVASION; GROWTH;

D O I：

10.3390/cells11223698

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential; numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.

引用

页数：23

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