The Regulation and Physiology of Mitochondrial Proton Leak

被引：347
|
作者：
Divakaruni, Ajit S. [1 ,2 ]
Brand, Martin D. [1 ,2 ]
机构：
[1] Wellcome Trust Res Labs, Med Res Council Mitochondrial Biol Unit, Cambridge, England
[2] Buck Inst Res Aging, Novato, CA USA
来源：
PHYSIOLOGY | 2011年 / 26卷 / 03期
基金：
美国国家科学基金会;
关键词：
BROWN-ADIPOSE-TISSUE; HUMAN UNCOUPLING PROTEIN-3; SKELETAL-MUSCLE MITOCHONDRIA; POLYUNSATURATED FATTY-ACIDS; SPARE RESPIRATORY CAPACITY; BETA-ADRENERGIC-RECEPTORS; DIET-INDUCED OBESITY; FREE-RADICAL THEORY; LIVER-MITOCHONDRIA; INNER MEMBRANE;
D O I：
10.1152/physiol.00046.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.
引用
收藏
页码：192 / 205
页数：14
相关论文
共 50 条
  • [21] The regulation of tumor cell physiology by mitochondrial dynamics
    Kashatus, David F.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 500 (01) : 9 - 16
  • [22] Regulation of mitochondrial proteostasis by the proton gradient
    Patron, Maria
    Tarasenko, Daryna
    Nolte, Hendrik
    Kroczek, Lara
    Ghosh, Mausumi
    Ohba, Yohsuke
    Lasarzewski, Yvonne
    Ahmadi, Zeinab Alsadat
    Cabrera-Orefice, Alfredo
    Eyiama, Akinori
    Kellermann, Tim
    Rugarli, Elena, I
    Brandt, Ulrich
    Meinecke, Michael
    Langer, Thomas
    EMBO JOURNAL, 2022, 41 (16):
  • [23] Regulation of mitochondrial proteostasis by the proton gradient
    Langer, Thomas
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2022, 1863 : 6 - 6
  • [24] Regulation and physiology of the mitochondrial calcium uniporter MCU
    Szabo, I.
    ACTA PHYSIOLOGICA, 2015, 213 : 10 - 10
  • [25] Increased mitochondrial proton leak in hepatocytes from old mice.
    Harper, ME
    Monemdjou, S
    Weindruch, R
    Ramsey, JJ
    FASEB JOURNAL, 1997, 11 (03): : 1022 - 1022
  • [26] Mechanisms of cardiac mitochondrial proton leak in preconditioning and ischemia-reperfusion
    Nadtochiy, SM
    Tompkins, AJ
    Brookes, PS
    BIOPHYSICAL JOURNAL, 2005, 88 (01) : 548A - 548A
  • [27] Phylogenetic analysis of the allometry of metabolic rate and mitochondrial basal proton leak
    Polymeropoulos, Elias T.
    Oelkrug, R.
    White, C. R.
    Jastroch, M.
    JOURNAL OF THERMAL BIOLOGY, 2017, 68 : 83 - 88
  • [28] Mitochondrial Proton Leak Plays a Critical Role in Pathogenesis of Cardiovascular Diseases
    Cheng, Jiali
    Nanayakkara, Gayani
    Shao, Ying
    Cueto, Ramon
    Wang, Luqiao
    Yang, William Y.
    Tian, Ye
    Wang, Hong
    Yang, Xiaofeng
    MITOCHONDRIAL DYNAMICS IN CARDIOVASCULAR MEDICINE, 2017, 982 : 359 - 370
  • [29] Nitrated lipids stimulate mitochondrial proton leak: Implications for ischemic preconditioning
    Brookes, Paul S.
    Nadtochiy, Sergiy M.
    Baker, Paul R. S.
    Freeman, Bruce a
    FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 : S138 - S138
  • [30] Energy expenditure and mitochondrial proton leak in lean and obese strains of rats
    Ramsey, JJ
    Johnson, DE
    Johnson, KA
    ENERGY METABOLISM OF FARM ANIMALS, 1998, : 27 - 30
12345