The Regulation and Physiology of Mitochondrial Proton Leak

被引：348
|
作者：
Divakaruni, Ajit S. [1 ,2 ]
Brand, Martin D. [1 ,2 ]
机构：
[1] Wellcome Trust Res Labs, Med Res Council Mitochondrial Biol Unit, Cambridge, England
[2] Buck Inst Res Aging, Novato, CA USA
来源：
PHYSIOLOGY | 2011年 / 26卷 / 03期
基金：
美国国家科学基金会;
关键词：
BROWN-ADIPOSE-TISSUE; HUMAN UNCOUPLING PROTEIN-3; SKELETAL-MUSCLE MITOCHONDRIA; POLYUNSATURATED FATTY-ACIDS; SPARE RESPIRATORY CAPACITY; BETA-ADRENERGIC-RECEPTORS; DIET-INDUCED OBESITY; FREE-RADICAL THEORY; LIVER-MITOCHONDRIA; INNER MEMBRANE;
D O I：
10.1152/physiol.00046.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Mitochondria couple respiration to ATP synthesis through an electrochemical proton gradient. Proton leak across the inner membrane allows adjustment of the coupling efficiency. The aim of this review is threefold: 1) introduce the unfamiliar reader to proton leak and its physiological significance, 2) review the role and regulation of uncoupling proteins, and 3) outline the prospects of proton leak as an avenue to treat obesity, diabetes, and age-related disease.
引用
收藏
页码：192 / 205
页数：14
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