Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery

被引：62
|
作者：
Xu, Peisheng [1 ]
Li, Shi-Yan [2 ]
Li, Qun [2 ]
Van Kirk, Edward A. [3 ]
Ren, Jun [2 ]
Murdoch, William J. [3 ]
Zhang, Zhaojie [4 ]
Radosz, Maciej [1 ]
Shen, Youqing [1 ]
机构：
[1] Univ Wyoming, Sch Pharm, Laramie, WY 82071 USA
[2] Univ Wyoming, Dept Chem & Petr Engn, Laramie, WY 82071 USA
[3] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA
[4] Univ Wyoming, Microscopy Core Facil, Laramie, WY 82071 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期
关键词：
DNA; gene delivery; nanostructures; polymers; self-assembly;
D O I：
10.1002/anie.200703203
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A new concept for fabricating nanocarriers carrying free DNA for gene delivery to overcome the intracellular dissociation barrier of cationic polymer/DNA complexes is presented. Free DNA plasmids (shown in green) are encapsulated in a nanocapsule core, which is protected by a hydrophobicmembrane (purple) with a poly(ethylene glycol) outer layer (blue). The nanocapsules can release free DNA into the cells and have high in vitro and in vivo transfection efficiency. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1260 / 1264
页数：5
相关论文
共 50 条
  • [21] Charged Diphenylalanine Nanotubes and Controlled Hierarchical Self-Assembly
    Wang, Minjie
    Du, Lingjie
    Wu, Xinglong
    Xiong, Shijie
    Chu, Paul K.
    ACS NANO, 2011, 5 (06) : 4448 - 4454
  • [22] Self-Assembly of Hierarchical Nanostructures from Dopamine and Polyoxometalate for Oral Drug Delivery
    Li, Hong
    Jia, Yi
    Wang, Anhe
    Cui, Wei
    Ma, Hongchao
    Feng, Xiyun
    Li, Junbai
    CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (02) : 499 - 504
  • [23] pH-Controlled Molecular Switches and the Substrate-Directed Self-Assembly of Molecular Capsules with a Calix[4]pyrrole Derivative
    Cafeo, Grazia
    Kohnke, Franz H.
    Valenti, Luca
    White, Andrew J. P.
    CHEMISTRY-A EUROPEAN JOURNAL, 2008, 14 (36) : 11593 - 11600
  • [24] Organocounterions-Assisted and pH-Controlled Self-Assembly of Five Nanoscale High-Nuclear Lanthanide Substituted Heteropolytungstates
    Liu, Yajie
    Li, Hailou
    Lu, Changtong
    Gong, Peijun
    Ma, Xiaoyun
    Chen, Lijuan
    Zhao, Junwei
    CRYSTAL GROWTH & DESIGN, 2017, 17 (07) : 3917 - 3928
  • [25] Uranyl-peroxide nanocapsules: From self-assembly to isomerism
    Miro, Pere
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [26] Self-assembly of biodegradable polyurethanes for controlled delivery applications
    Ding, Mingming
    Li, Jiehua
    Tan, Hong
    Fu, Qiang
    SOFT MATTER, 2012, 8 (20) : 5414 - 5428
  • [27] Controlled Fabrication of Polydopamine Nanocapsules via Polymerization-Induced Self-Assembly
    Yu, Shui
    Ye, Zhicheng
    Liu, Zhiqing
    Sheng, Wenbo
    Li, Rui
    Zhao, Zeyu
    Shang, Yazhuo
    Li, Meng
    Li, Yongsheng
    Jia, Xin
    CHEMISTRY OF MATERIALS, 2022, 34 (19) : 8705 - 8710
  • [28] Self-assembly of a virus-mimicking nanostructure system for efficient tumor-targeted gene delivery
    Xu, L
    Frederik, P
    Pirollo, KF
    Tang, WH
    Rait, A
    Xiang, LM
    Huang, WQ
    Cruz, I
    Yin, YZ
    Chang, EH
    HUMAN GENE THERAPY, 2002, 13 (03) : 469 - 481
  • [29] Thermo- and pH-Responsive Copolymers Bearing Cholic Acid and Oligo(ethylene glycol) Pendants: Self-Assembly and pH-Controlled Release
    Jia, Yong-Guang
    Zhu, X. X.
    ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (44) : 24649 - 24655
  • [30] Controlled hierarchical self-assembly and deposition of nanoscale photonic materials
    Milic, TN
    Chi, N
    Yablon, DG
    Flynn, GW
    Batteas, JD
    Drain, CM
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, 41 (12) : 2117 - 2119
12345