Virion-mimicking nanocapsules from pH-controlled hierarchical self-assembly for gene delivery

被引：62
|
作者：
Xu, Peisheng [1 ]
Li, Shi-Yan [2 ]
Li, Qun [2 ]
Van Kirk, Edward A. [3 ]
Ren, Jun [2 ]
Murdoch, William J. [3 ]
Zhang, Zhaojie [4 ]
Radosz, Maciej [1 ]
Shen, Youqing [1 ]
机构：
[1] Univ Wyoming, Sch Pharm, Laramie, WY 82071 USA
[2] Univ Wyoming, Dept Chem & Petr Engn, Laramie, WY 82071 USA
[3] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA
[4] Univ Wyoming, Microscopy Core Facil, Laramie, WY 82071 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期
关键词：
DNA; gene delivery; nanostructures; polymers; self-assembly;
D O I：
10.1002/anie.200703203
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) A new concept for fabricating nanocarriers carrying free DNA for gene delivery to overcome the intracellular dissociation barrier of cationic polymer/DNA complexes is presented. Free DNA plasmids (shown in green) are encapsulated in a nanocapsule core, which is protected by a hydrophobicmembrane (purple) with a poly(ethylene glycol) outer layer (blue). The nanocapsules can release free DNA into the cells and have high in vitro and in vivo transfection efficiency. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：1260 / 1264
页数：5
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