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- [41] Immunochemoconjugate of anti-DNMT1/HDAC2 bispecific F(ab)2-bsAb linked with cleavable disulfide to vinorelbine induces apoptosis in chemoresistant infiltrating ductal carcinoma (IDC) characterised by HDAC2 overexpression and 5′CpG island hypermethylation of the FHIT, RAR-β2, BRCA-1, APC, p16(CDKN2A), RASSF1A, COH1 (E-cadherin), 14-3-3-σ(stratifin), HIC1 and MDG1 tumor suppressor genes. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (14) : 149S - 149S