Long-term colony housing in Long Evans rats: immunological, hormonal, and behavioral consequences

被引：39

作者：

Stefanski, V ^{[1
]}

Knopf, G ^{[1
]}

Schulz, S ^{[1
]}

机构：

[1] Univ Bayreuth, Dept Anim Physiol, D-95440 Bayreuth, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 114卷 / 1-2期

关键词：

chronic social stress; T cells; blood cellular immunity; hormones; subdominance; rat colony;

D O I：

10.1016/S0165-5728(00)00464-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The distribution pattern and the function of blood immune cells were investigated for 10 weeks in three mixed-sex colonies of Long Evans rats. After colony formation, a despotic dominance system was established between the males. This paper focuses on differences between subdominant colony and pair-housed control males. A reduced body mass development and hormonal status in subdominant males indicate stressful colony conditions. Subdominant males had lower numbers of CD4 and CD8 T cells, pronounced granulocytosis and reduced lymphocyte proliferation rates as compared with controls. The persistency of changes in subdominant males offers the opportunity to investigate the effects of long-term immune-modulation on health. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：122 / 130

页数：9

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