Marked thrombocytopenia in a neonate is associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies

被引：6

作者：

Okubo, Mitsuo ^{[1
,2
]}

Nishida, Eriko ^{[3
]}

Watanabe, Akiko ^{[3
]}

Nishizaki, Naoto ^{[3
]}

Obinata, Kaoru ^{[3
]}

Azuma, Fumihiro ^{[4
]}

Matsuhashi, Mika ^{[4
]}

Watanabe-Okochi, Naoko ^{[4
]}

Tsuno, Nelson Hirokazu ^{[4
]}

Miyake, Kazunori ^{[5
]}

Yamaguchi, Minoru ^{[6
]}

Yoshida, Koyo ^{[7
]}

Ohsaka, Akimichi ^{[2
]}

机构：

[1] Juntendo Univ Urayasu Hosp, Dept Transfus Serv, Urayasu, Chiba 2790021, Japan

[2] Juntendo Univ, Grad Sch Med, Dept Transfus Med & Stem Cell Regulat, Tokyo, Japan

[3] Juntendo Univ Urayasu Hosp, Dept Pediat, Urayasu, Japan

[4] Japanese Red Cross, Kanto Koshinetsu Block Blood Ctr, Lab Dept, Tokyo, Japan

[5] Juntendo Univ Urayasu Hosp, Dept Lab Med, Urayasu, Japan

[6] Yamaguchi Hosp, Funabashi, Chiba, Japan

[7] Juntendo Univ Urayasu Hosp, Dept Obstet & Gynecol, Urayasu, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 03期

关键词：

fetal and neonatal alloimmune thrombocytopenia; HLA; human platelet antigen; thrombocytopenia; PLATELET TRANSFUSION REFRACTORINESS; ALLOIMMUNE THROMBOCYTOPENIA; HLA ANTIBODIES; ALLOANTIBODY; ANTIGEN; FETAL;

D O I：

10.1002/pbc.27555

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 0.09-0.15% of live births. Severe cases account for 5-31% and the frequency of multiple kinds of alloantibodies is 6.9-9% of FNAIT. We present a case of severe FNAIT associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies, successfully treated with immunoglobulin and platelet transfusion. The anti-HLA-B55 antibody was detected in the newborn's serum, but disappeared on the 20th day, which was followed by an increase of the platelet count. These findings suggested the potential involvement of an anti-HLA antibody in the pathogenesis of FNAIT.

引用

页数：4

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