Marked thrombocytopenia in a neonate is associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies

被引：6

作者：

Okubo, Mitsuo ^{[1
,2
]}

Nishida, Eriko ^{[3
]}

Watanabe, Akiko ^{[3
]}

Nishizaki, Naoto ^{[3
]}

Obinata, Kaoru ^{[3
]}

Azuma, Fumihiro ^{[4
]}

Matsuhashi, Mika ^{[4
]}

Watanabe-Okochi, Naoko ^{[4
]}

Tsuno, Nelson Hirokazu ^{[4
]}

Miyake, Kazunori ^{[5
]}

Yamaguchi, Minoru ^{[6
]}

Yoshida, Koyo ^{[7
]}

Ohsaka, Akimichi ^{[2
]}

机构：

[1] Juntendo Univ Urayasu Hosp, Dept Transfus Serv, Urayasu, Chiba 2790021, Japan

[2] Juntendo Univ, Grad Sch Med, Dept Transfus Med & Stem Cell Regulat, Tokyo, Japan

[3] Juntendo Univ Urayasu Hosp, Dept Pediat, Urayasu, Japan

[4] Japanese Red Cross, Kanto Koshinetsu Block Blood Ctr, Lab Dept, Tokyo, Japan

[5] Juntendo Univ Urayasu Hosp, Dept Lab Med, Urayasu, Japan

[6] Yamaguchi Hosp, Funabashi, Chiba, Japan

[7] Juntendo Univ Urayasu Hosp, Dept Obstet & Gynecol, Urayasu, Japan

来源：

PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 03期

关键词：

fetal and neonatal alloimmune thrombocytopenia; HLA; human platelet antigen; thrombocytopenia; PLATELET TRANSFUSION REFRACTORINESS; ALLOIMMUNE THROMBOCYTOPENIA; HLA ANTIBODIES; ALLOANTIBODY; ANTIGEN; FETAL;

D O I：

10.1002/pbc.27555

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Maternal antibodies against human platelet antigen (HPA) and/or human leukocyte antigen (HLA) cause fetal and neonatal alloimmune thrombocytopenia (FNAIT) in 0.09-0.15% of live births. Severe cases account for 5-31% and the frequency of multiple kinds of alloantibodies is 6.9-9% of FNAIT. We present a case of severe FNAIT associated with anti-HPA-5b, anti-HLA-A31, and anti-HLA-B55 antibodies, successfully treated with immunoglobulin and platelet transfusion. The anti-HLA-B55 antibody was detected in the newborn's serum, but disappeared on the 20th day, which was followed by an increase of the platelet count. These findings suggested the potential involvement of an anti-HLA antibody in the pathogenesis of FNAIT.

引用

页数：4

共 50 条

[1] Anti-HPA-5b Antibodies in fetal and neonatal Alloimmune Thrombocytopenia
Maier, Alexander
TRANSFUSIONSMEDIZIN, 2022, 12 (03) : 145 - 146
[2] Severe neonatal alloimmune thrombocytopenia with anti-HPA-5B antibodies: case report
不详
VOX SANGUINIS, 2005, 89 : 157 - 157
[3] THROMBOCYTOPENIA CAUSED BY PASSIVE TRANSFUSION OF ANTI-GLYCOPROTEIN IA/IIA ALLOANTIBODY (ANTI-HPA-5B)
WARKENTIN, TE
SMITH, JW
HAYWARD, CPM
ALI, AM
KELTON, JG
BLOOD, 1992, 79 (09) : 2480 - 2484
[4] Alloimmune neonatal neutropenia and thrombocytopenia associated with maternal anti HNA-1a, HPA-3b and HLA antibodies
Marín, L
Torío, A
Muro, M
Fernandez-Parra, R
Minguela, A
Bosch, V
Alvarez-López, MR
García-Alonso, AM
PEDIATRIC ALLERGY AND IMMUNOLOGY, 2005, 16 (03) : 279 - 282
[5] ANTI-HLA-A, ANTI-HLA-B, ANTI-HLA-C AND ANTI-HLA-DR ANTIBODIES IN RENAL-TRANSPLANT RECIPIENTS
AKIYAMA, N
KUSABA, R
OSAWA, N
INOU, T
KAWAMURA, A
JAPANESE JOURNAL OF EXPERIMENTAL MEDICINE, 1980, 50 (03): : 205 - 211
[6] A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy
Kiyokawa, Tomoko
Koh, Yangsook
Mimura, Kazuya
Nakayama, Kotarosumitomo
Hosokawa, Mika
Sakuragi, Mikiko
Morikawa, Tamayo
Nakao, Mayumi
Aochi, Hiroshi
Fukumori, Yasuo
Kanagawa, Takeshi
Nagamine, Keisuke
Kimura, Tadashi
Tomiyama, Yoshiaki
INTERNATIONAL JOURNAL OF HEMATOLOGY, 2014, 100 (04) : 398 - 401
[7] Incidental diagnosis and tempestive therapy in a case of neonatal alloimmune thrombocytopenia due to anti-HPA-5b
Zuppa, AA
Cota, F
De Luca, D
Visintini, F
De Turris, PL
Tortorolo, G
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2002, 19 (08) : 587 - 591
[8] Study of the First Case of Neonatal Alloimmune Thrombocytopenia Associated with Anti-HPA-5b and HPA-5 Genetic Frequency in a Chinese Population
Zhou, Y.
Li, L.
Liu, J.
Zhong, Z.
Shen, W.
Wu, G.
TRANSFUSION, 2014, 54 : 223A - 223A
[9] A case of neonatal alloimmune thrombocytopenia in the presence of both anti-HPA-4b and anti-HPA-5b antibody: clinical and serological analysis of the subsequent pregnancy
Tomoko Kiyokawa
Yangsook Koh
Kazuya Mimura
Kotarosumitomo Nakayama
Mika Hosokawa
Mikiko Sakuragi
Tamayo Morikawa
Mayumi Nakao
Hiroshi Aochi
Yasuo Fukumori
Takeshi Kanagawa
Keisuke Nagamine
Tadashi Kimura
Yoshiaki Tomiyama
International Journal of Hematology, 2014, 100 : 398 - 401
[10] Spontaneous rise of fetal platelet counts despite increasing anti-HPA-5b antibodies
Ulm, B
Ulm, MR
Deutinger, J
Eichelberger, B
Panzer, S
VOX SANGUINIS, 1997, 72 (02) : 111 - 113

← 1 2 3 4 5 →