Discovery of thienoimidazole-based HCV NS5A genotype 1a and 1b inhibitors

被引:0
|
作者
Giroux, Simon [1 ]
Xu, Jinwang [1 ]
Reddy, T. Jagadeeswar [2 ]
Morris, Mark [1 ]
Cottrell, Kevin M. [1 ]
Cadilhac, Caroline [2 ]
Henderson, James A. [1 ]
Nicolas, Olivier [3 ]
Bilimoria, Darius [3 ]
Mani, Nagraj [4 ]
Ewing, Nigel [5 ]
Shawgo, Rebecca [5 ]
L'Heureux, Lucille [3 ]
Selliah, Subajini [3 ]
Grillot, Anne-Laure [1 ]
Bennani, Youssef L. [2 ]
Maxwell, John P. [1 ]
机构
[1] Vertex Pharmaceut, Med Chem, Boston, MA 02210 USA
[2] Vertex Pharmaceut Canada Inc, Med Chem, Laval, PQ H7V 4A7, Canada
[3] Vertex Pharmaceut Canada Inc, Biol, Laval, PQ H7V 4A7, Canada
[4] Vertex Pharmaceut, Biol, Boston, MA 02210 USA
[5] Vertex Pharmaceut, Drug Metab & Pharmacokinet, Boston, MA 02210 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 248卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
79-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [11] "OTHELLO HYPOTHESIS" INVOLVED IN THE DEVELOPMENT OF RAVS TOLERANT TO NS5A INHIBITORS IN PATIENTS WITH GENOTYPE 1B HCV INFECTION
    Uchida, Y.
    Kouyama, J-I.
    Naiki, K.
    Sugawara, K.
    Inao, M.
    Imai, Y.
    Nakayama, N.
    Mochida, S.
    JOURNAL OF HEPATOLOGY, 2016, 64 : S410 - S411
  • [12] Susceptibilities of Genotype 1a, 1b, and 3 Hepatitis C Virus Variants to the NS5A Inhibitor Elbasvir
    Liu, Rong
    Curry, Stephanie
    McMonagle, Patricia
    Yeh, Wendy W.
    Ludmerer, Steven W.
    Jumes, Patricia A.
    Marshall, William L.
    Kong, Stephanie
    Ingravallo, Paul
    Black, Stuart
    Pak, Irene
    DiNubile, Mark J.
    Howe, Anita Y. M.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (11) : 6922 - 6929
  • [13] Discovery of fluorobenzimidazole HCV NS5A inhibitors
    Randolph, John
    Flentge, Charles
    Patel, Sachin
    Nelson, Lissa
    Mondal, Rubina
    Mistry, Neeta
    Reisch, Tom
    Dekhtyar, Tatyana
    Krishnan, Preethi
    Pilot-Matias, Tami
    Beno, David
    Wagner, Rolf
    Kati, Warren
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [14] Discovery of fluorobenzimidazole HCV NS5A inhibitors
    Randolph, John T.
    Flentge, Charles A.
    Donner, Pamela
    Rockway, Todd W.
    Patel, Sachin V.
    Nelson, Lissa
    Hutchinson, Douglas K.
    Mondal, Rubina
    Mistry, Neeta
    Reisch, Thomas
    Dekhtyar, Tatyana
    Krishnan, Preethi
    Pilot-Matias, Tami
    Stolarik, Deanne F.
    Beno, David W. A.
    Wagner, Rolf
    Maring, Clarence
    Kati, Warren M.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (22) : 5462 - 5467
  • [15] Discovery of potent HCV NS5A inhibitors with pan-genotype activity
    Yu, Wensheng
    Chen, Lei
    Dwyer, Michael
    Keertikar, Kerry
    Kim, Seong Heon
    Lavey, Brian
    Nair, Anilkumar
    Rizvi, Razia
    Rosenblum, Stuart
    Selyutin, Oleg
    Shankar, Bandarpalle
    Tong, Ling
    Wong, Michael
    Yang, De-Yi
    Zeng, Qingbei
    Zhou, Guowei
    Hu, Bin
    Zhong, Bin
    Wang, Dahai
    Hao, Jinglai
    Liu, Rong
    Agrawal, Sony
    Carr, Donna
    Rokosz, Laura
    Curry, Stephanie
    McMonagle, Patricia
    Ingravallo, Paul
    Lahser, Fred
    Asante-Appiah, Ernest
    Nomeir, Amin
    Coburn, Craig
    Kozlowski, Joseph
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [16] An mTor-based immunosuppression reduces the antiviral efficacy of NS3/4A and NS5A inhibitors for HCV genotype 1b treatment in vitro
    Frey, Alexandra
    Walker, Andreas
    Timm, Joerg
    Gerken, Guido
    Wedemeyer, Heiner
    Herzer, Kerstin
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E829 - E829
  • [17] Discovery of potent macrocyclic HCV NS5A inhibitors
    Yu, Wensheng
    Vibulbhan, Bancha
    Rosenblum, Stuart B.
    Martin, Gregory S.
    Vellekoop, A. Samuel
    Holst, Christian L.
    Coburn, Craig A.
    Wong, Michael
    Selyutin, Oleg
    Ji, Tao
    Zhong, Bin
    Hu, Bin
    Chen, Lei
    Dwyer, Michael P.
    Jiang, Yueheng
    Nair, Anilkumar G.
    Tong, Ling
    Zeng, Qingbei
    Agrawal, Sony
    Carr, Donna
    Rokosz, Laura
    Liu, Rong
    Curry, Stephanie
    McMonagle, Patricia
    Ingravallo, Paul
    Lahser, Fred
    Asante-Appiah, Ernest
    Fells, James
    Kozlowski, Joseph A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (15) : 3793 - 3799
  • [18] Strong HCV NS3/4a, NS4b, NS5a, NS5b-specific cellular immune responses induced in Rhesus macaques by a novel HCV genotype 1a/1b consensus DNA vaccine
    Latimer, Brian
    Toporovski, Roberta
    Yan, Jian
    Pankhong, Panyupa
    Morrow, Matthew P.
    Khan, Amir S.
    Sardesai, Niranjan Y.
    Welles, Seth L.
    Jacobson, Jeffrey M.
    Weiner, David B.
    Kutzler, Michele A.
    HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2014, 10 (08) : 2357 - 2365
  • [19] The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors
    Lambert, Sebastian M.
    Langley, David R.
    Garnett, James A.
    Angell, Richard
    Hedgethorne, Katy
    Meanwell, Nicholas A.
    Matthews, Steve J.
    PROTEIN SCIENCE, 2014, 23 (06) : 723 - 734
  • [20] Investigating Genotype 1a HCV Drug Resistance in NS5A Region via Bayesian Inference
    Fu, Yao
    Chen, Gang
    Fu, Lizhi
    Zhang, Jing
    TSINGHUA SCIENCE AND TECHNOLOGY, 2015, 20 (05) : 484 - 490