Discovery of thienoimidazole-based HCV NS5A genotype 1a and 1b inhibitors

被引:0
|
作者
Giroux, Simon [1 ]
Xu, Jinwang [1 ]
Reddy, T. Jagadeeswar [2 ]
Morris, Mark [1 ]
Cottrell, Kevin M. [1 ]
Cadilhac, Caroline [2 ]
Henderson, James A. [1 ]
Nicolas, Olivier [3 ]
Bilimoria, Darius [3 ]
Mani, Nagraj [4 ]
Ewing, Nigel [5 ]
Shawgo, Rebecca [5 ]
L'Heureux, Lucille [3 ]
Selliah, Subajini [3 ]
Grillot, Anne-Laure [1 ]
Bennani, Youssef L. [2 ]
Maxwell, John P. [1 ]
机构
[1] Vertex Pharmaceut, Med Chem, Boston, MA 02210 USA
[2] Vertex Pharmaceut Canada Inc, Med Chem, Laval, PQ H7V 4A7, Canada
[3] Vertex Pharmaceut Canada Inc, Biol, Laval, PQ H7V 4A7, Canada
[4] Vertex Pharmaceut, Biol, Boston, MA 02210 USA
[5] Vertex Pharmaceut, Drug Metab & Pharmacokinet, Boston, MA 02210 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
79-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors
    Giroux, Simon
    Xu, Jinwang
    Reddy, T. Jagadeeswar
    Morris, Mark
    Cottrell, Kevin M.
    Cadilhac, Caroline
    Henderson, James A.
    Nicolas, Oliver
    Bilimoria, Darius
    Denis, Francois
    Mani, Nagraj
    Ewing, Nigel
    Shawgo, Rebecca
    L'Heureux, Lucille
    Selliah, Subajini
    Chan, Laval
    Chauret, Nathalie
    Berlioz-Seux, Francoise
    Namchuk, Mark N.
    Grillot, Anne-Laure
    Bennani, Youssef L.
    Das, Sanjoy K.
    Maxwell, John P.
    ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (03): : 240 - 243
  • [2] Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b
    Giroux, Simon
    Bilimoria, Darius
    Cadilhac, Caroline
    Cottrell, Kevin M.
    Denis, Francois
    Dietrich, Evelyne
    Ewing, Nigel
    Henderson, James A.
    L'Heureux, Lucille
    Mani, Nagraj
    Morris, Mark
    Nicolas, Olivier
    Reddy, T. Jagadeeswar
    Selliah, Subajini
    Shawgo, Rebecca S.
    Xu, Jinwang
    Chauret, Nathalie
    Berlioz-Seux, Francoise
    Chan, Laval C.
    Das, Sanjoy K.
    Grillot, Anne-Laure
    Bennani, Youssef L.
    Maxwell, John P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 940 - 943
  • [3] Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers
    Giroux, Simon
    Bilimoria, Darius
    Cadilhac, Caroline
    Cottrell, Kevin M.
    Denis, Francois
    Dietrich, Evelyne
    Ewing, Nigel
    Henderson, James A.
    L'Heureux, Lucille
    Mani, Nagraj
    Morris, Mark
    Nicolas, Olivier
    Reddy, T. Jagadeeswar
    Selliah, Subajini
    Shawgo, Rebecca S.
    Xu, Jinwang
    Chauret, Nathalie
    Berlioz-Seux, Francoise
    Chan, Laval C.
    Das, Sanjoy K.
    Grillot, Anne-Laure
    Bennani, Youssef L.
    Maxwell, John P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 936 - 939
  • [4] HCV NS5A replication complex inhibitors: Effects of substituted pyrrolidines in balancing genotype 1a/1b potency
    Henderson, James A.
    Liu, Bingcan
    Giroux, Simon
    Reddy, T. Jagadeeswar
    Bubenik, Monica
    Cadilhac, Caroline
    Vaillancourt, Louis
    Falardeau, Guy
    Poisson, Carl
    Pereira, Oswy
    Cottrell, Kevin M.
    Morris, Mark
    Nicolas, Olivier
    Bilimoria, Darius
    Mani, Nagraj
    Ewing, Nigel
    Shawgo, Rebecca
    L'Heureux, Lucille
    Selliah, Subajini
    Grillot, Anne-Laure
    Bennani, Youssef L.
    Maxwell, John P.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [5] HCV NS5A mutations in Europeans infected by genotype 1b
    Magrin, S
    Fabiano, C
    Gianguzza, F
    Cutrera, M
    Alaimo, G
    Pagliaro, L
    GASTROENTEROLOGY, 1998, 115 (01) : 244 - 245
  • [6] Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
    Henderson, James A.
    Bilimoria, Darius
    Bubenik, Monica
    Cadilhac, Caroline
    Cottrell, Kevin M.
    Dietrich, Evelyne
    Denis, Francois
    Ewing, Nigel
    Falardeau, Guy
    Giroux, Simon
    Grey, Ronald, Jr.
    L'Heureux, Lucille
    Liu, Bingcan
    Mani, Nagraj
    Morris, Mark
    Nicolas, Olivier
    Pereira, Oswy Z.
    Poisson, Carl
    Rao, B. Govinda
    Reddy, T. Jagadeeswar
    Selliah, Subajini
    Shawgo, Rebecca S.
    Vaillancourt, Louis
    Wang, Jian
    Yannopoulos, Constantin G.
    Chauret, Nathalie
    Berlioz-Seux, Francoise
    Chan, Laval C.
    Das, Sanjoy K.
    Grillot, Anne-Laure
    Bennani, Youssef L.
    Maxwell, John P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 25 (04) : 944 - 947
  • [7] Prevalence of baseline HCV NS5A resistance associated substitutions in genotype 1a, 1b and 3 infection in Australia
    Papaluca, T.
    O'Keefe, J.
    Bowden, S.
    Doyle, J. S.
    Stoove, M.
    Hellard, M.
    Thompson, A. J.
    JOURNAL OF CLINICAL VIROLOGY, 2019, 120 : 84 - 87
  • [8] Hepatitis C virus NS5A polymorphisms in patients with HCV genotype 1B
    Shimizu, Yuko
    Hayashi, Kazuhiko
    Mori, Hiroshi
    Toriyama, Kazuhiro
    Yoshizaki, Michiyo
    Furune, Satoshi
    Takenaka, Hiroyuki
    Hayashi, Takao
    Matuura, Tetuo
    Kuroiwa, Masanori
    Morita, Keiichi
    Ishigami, Masatoshi
    Goto, Hidemi
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2014, 29 : 203 - 203
  • [9] Mutations in the NS5A gene of hepatitis C virus in North American patients infected with HCV genotype 1a or 1b
    Hofgartner, WT
    Polyak, SJ
    Sullivan, DG
    Carithers, RL
    Gretch, DR
    JOURNAL OF MEDICAL VIROLOGY, 1997, 53 (02) : 118 - 126
  • [10] The incidence of resistance-associated variants to NS5A in HCV subtypes 1a and 1b in Taiwan
    Tsai, Ming-Chao
    Hung, Chao-Hung
    Lu, Sheng-Nan
    Wang, Jing-Houng
    Chen, Chien-Hung
    Kee, Kwong-Ming
    Chang, Kuo-Chin
    Chao, Tsai-Ling
    Hu, Tsung-Hui
    BIOMEDICAL JOURNAL, 2021, 44 (06) : S126 - S131