Iridium-Catalyzed Enantioselective Hydrogenation of Indole and Benzofuran Derivatives

被引：25

作者：

Ge, Yao ^{[1
,2
]}

Wang, Zheng ^{[1
]}

Han, Zhaobin ^{[1
]}

Ding, Kuiling ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Organometall Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[3] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 67期

关键词：

asymmetric catalysis; benzofurans; benzothiophene; 1; 1-dioxides; hydrogenation; indoles; iridium; CONVERTING ENZYME-INHIBITORS; DNA-POLYMERASE-BETA; ASYMMETRIC HYDROGENATION; MECHANISTIC INSIGHTS; OXAZOLINE LIGANDS; POTENT; ACID; COMPLEXES; PYRIDINE; (+)-MYRISTININ-A;

D O I：

10.1002/chem.202002532

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantioselective hydrogenation of a broad spectrum of N-, O-, and S-containing aromatic benzoheterocycles or nonaromatic unsaturated heterocycles has been realized by using an Ir/SpinPHOX (SpinPHOX=spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline) complex as the catalyst, affording an array of the corresponding chiral benzoheterocycles (30 examples) with excellent enantioselectivities (>99 % eein most cases) and turnover numbers up to 500.

引用

页码：15482 / 15486

页数：5

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