Anti-phosphatidylserine/prothrombin antibodies are not frequently found in patients with unexplained recurrent miscarriages

被引:13
|
作者
Tsutsumi, A
Atsumi, T
Yamada, H
Kato, EH
Ichikawa, K
Fujimoto, S
Koike, T
机构
[1] Hokkaido Univ, Sch Med, Dept Med 2, Kita Ku, Sapporo, Hokkaido 0608635, Japan
[2] Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 0608635, Japan
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2001年 / 46卷 / 03期
关键词
Anti-phosphatidylserine/prothrombin antibody; anti-phospholipid syndrome; anti-pro thrombin antibody; recurrent miscarriage;
D O I
10.1034/j.1600-0897.2001.d01-8.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
OBJECTIVE: To determine whether the presence of anti-phosphatidylserine/ prothrombin antibodies (anti-PS/PT) can be a major factor in otherwise Unexplained recurrent miscarriages. PATIENTS AND METHODS: Eighty-one consecutive patients with history of 2 or more recurrent miscarriages were studied. Patients with history of overt thrombotic events were not included. Patients were examined for plausible causes of miscarriages, and titer of IgG, I-M and IgA anti-PS/PT were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Thirty-five patients had one or more plausible causes of recurrent miscarriages, including 12 positive for well-established anti-phospholipid antibodies, such as anti-beta2-glycoprotein I. None of the patients included in this study was found to be positive for anti-PS/PT. CONCLUSION: Detection of anti-PS/PT in addition to other anti-phospholipid antibodies does not seem to aid in the evaluation of patients with unexplained recurrent miscarriages.
引用
收藏
页码:242 / 244
页数:3
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