No influence on disease progression of non-HLA susceptibility genes in MS

被引：8

作者：

Lundstrom, Wangko ^{[1
]}

Greiner, Eva ^{[1
]}

Lundmark, Frida ^{[1
]}

Westerlind, Helga ^{[1
]}

Smestad, Cathrine ^{[2
]}

Lorentzen, Aslaug R. ^{[2
,3
]}

Kockum, Ingrid ^{[1
]}

Link, Jenny ^{[1
]}

Brynedal, Boel ^{[1
]}

Celius, Elisabeth G. ^{[2
]}

Harbo, Hanne F. ^{[2
,4
]}

Masterman, Thomas ^{[1
]}

Hillert, Jan ^{[1
]}

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Ctr Mol Med, Multiple Sclerosis Res Grp, Stockholm, Sweden

[2] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[3] Oslo Univ Hosp, Inst Immunol, Rikshosp, Oslo, Norway

[4] Univ Oslo, Oslo, Norway

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2011年 / 237卷 / 1-2期

关键词：

Multiple sclerosis; Severity; EDSS; MSSS; SNPs; Genotype; MULTIPLE-SCLEROSIS; RISK; DISABILITY; SEVERITY; ALLELES;

D O I：

10.1016/j.jneuroim.2011.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently, several non-HLA loci have been shown to be convincingly associated with Multiple Sclerosis (MS) susceptibility, assumingly indicating important pathways in the pathogenesis. A genotype influence on disease outcome measures by these genes would support a role of these pathways in ongoing tissue damage. Here, however, we report a consistent dissociation between causation and progression for five non-HLA genotypes (IL7R, IL2RA, CLEC16A, CD226 and SH2B3) in 1776 Scandinavian MS patients. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：98 / 100

页数：3

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