Prostate cancer and metastasis initiating stem cells

被引：43
|
作者：
Kelly, Kathleen [1 ]
Yin, Juan Juan [1 ]
机构：
[1] NCI, Cell & Canc Biol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
来源：
CELL RESEARCH | 2008年 / 18卷 / 05期
关键词：
prostate cancer; metastasis; stem; progenitor; androgen; hedgehog;
D O I：
10.1038/cr.2008.50
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Androgen refractory prostate cancer metastasis is a major clinical challenge. Mechanism-based approaches to treating prostate cancer metastasis require an understanding of the developmental origin of the metastasis-initiating cell. Properties of prostate cancer metastases such as plasticity with respect to differentiated phenotype and androgen independence are consistent with the transformation of a prostate epithelial progenitor or stem cell leading to metastasis. This review focuses upon current evidence and concepts addressing the identification and properties of normal prostate stem or progenitor cells and their transformed counterparts.
引用
收藏
页码：528 / 537
页数：10
相关论文
共 50 条
  • [21] Circulating metastasis-initiating cells in breast cancer
    Baccelli, Irene
    Riethdorf, Sabine
    Wallwiener, Markus
    Klein, Corinna
    Pantel, Klaus
    Weichert, Wilko
    Schneeweiss, Andreas
    Trumpp, Andreas
    CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (03) : 186 - 186
  • [22] Prostate stem cells and prostate cancer
    Lawson, D. A.
    Xin, L.
    Lukacs, R.
    Xu, Q.
    Cheng, D.
    Witte, O. N.
    Molecular Approaches to Controlling Cancer, 2005, 70 : 187 - 196
  • [23] Mitotic quiescence, but not unique "stemness," marks the phenotype of bone metastasis-initiating cells in prostate cancer
    Wang, Ning
    Docherty, Freyja
    Brown, Hannah K.
    Reeves, Kim
    Fowles, Anne
    Lawson, Michelle
    Ottewell, Penelope D.
    Holen, Ingunn
    Croucher, Peter I.
    Eaton, Colby L.
    FASEB JOURNAL, 2015, 29 (08): : 3141 - 3150
  • [24] Cancer stem cells, cancer-initiating cells and methods for their detection
    Akbari-Birgani, Shiva
    Paranjothy, Ted
    Zuse, Anna
    Janikowski, Tomasz
    Cieslar-Pobuda, Artur
    Likus, Wirginia
    Urasinska, Elzbieta
    Schweizer, Frank
    Ghavami, Saeid
    Kionisch, Thomas
    Los, Marek J.
    DRUG DISCOVERY TODAY, 2016, 21 (05) : 836 - 842
  • [25] Cancer Initiating Cells or Cancer Stem Cells in the Gastrointestinal Tract and Liver
    Zou, Gang-Ming
    JOURNAL OF CELLULAR PHYSIOLOGY, 2008, 217 (03) : 598 - 604
  • [26] Investigations of prostate epithelial stem cells and prostate cancer stem cells
    Miki, Jun
    INTERNATIONAL JOURNAL OF UROLOGY, 2010, 17 (02) : 139 - 147
  • [27] The Role of CD133 in Normal Human Prostate Stem Cells and Malignant Cancer-Initiating Cells
    Griend, Donald J. Vander
    Karthaus, Wouter L.
    Dalrymple, Susan
    Meeker, Alan
    DeMarzo, Angelo M.
    Isaacs, John T.
    CANCER RESEARCH, 2008, 68 (23) : 9703 - 9711
  • [28] Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
    George J. Klarmann
    Elaine M. Hurt
    Lesley A. Mathews
    Xiaohu Zhang
    Maria A. Duhagon
    Tashan Mistree
    Suneetha B. Thomas
    William L. Farrar
    Clinical & Experimental Metastasis, 2009, 26 : 433 - 446
  • [29] Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature
    Klarmann, George J.
    Hurt, Elaine M.
    Mathews, Lesley A.
    Zhang, Xiaohu
    Duhagon, Maria A.
    Mistree, Tashan
    Thomas, Suneetha B.
    Farrar, William L.
    CLINICAL & EXPERIMENTAL METASTASIS, 2009, 26 (05) : 433 - 446
  • [30] Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor
    Nishida, Sachiyo
    Hirohashi, Yoshihiko
    Torigoe, Toshihiko
    Inoue, Ryuta
    Kitamura, Hiroshi
    Tanaka, Toshiaki
    Takahashi, Akari
    Asanuma, Hiroko
    Masumori, Naoya
    Tsukamoto, Taiji
    Sato, Noriyuki
    CANCER SCIENCE, 2013, 104 (04) : 431 - 436
12345