Processing and evaluation of linear accelerator-produced 99Mo/99mTc in Canada

被引：22

作者：

Mang'era, Kennedy ^{[1
]}

Ogbomo, Kelly ^{[2
]}

Zriba, Riadh ^{[2
]}

Fitzpatrick, Jared ^{[2
]}

Brown, Jenna ^{[2
]}

Pellerin, Eric ^{[2
]}

Barnard, John ^{[3
]}

Saunders, Chris ^{[3
]}

de Jong, Mark ^{[4
]}

机构：

[1] Univ Manitoba, Radiol, Winnipeg, MB R3A 1R9, Canada

[2] Hlth Sci Ctr, Radiopharmaceut Res Grp, Winnipeg, MB R3E 3P5, Canada

[3] Acs Ind, Winnipeg, MB R3M 0W4, Canada

[4] Canadian Light Source Inc, Saskatoon, SK S7N 2V3, Canada

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2015年 / 305卷 / 01期

关键词：

Linear accelerator; Tc-99m-technetium; Mo-99-molybdenum; Solvent generator; Extractions; CYCLOTRON PRODUCTION; TC-99M; SEPARATION; GENERATOR; MO-99;

D O I：

10.1007/s10967-015-3997-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We are developing electron linear accelerator Mo-100(gamma,n)Mo-99 technology as a replacement to nuclear reactor U-235(n,f)Mo-99 production. We report irradiation of natural molybdenum disks (25 MeV, 10 kW) and Mo-100-enriched disks (35 MeV, 2 kW), their dissolution and the extraction of Tc-99m-pertechnetate. Up to 6.2 GBq Mo-99 was produced, solvent extraction was performed at > 90 % yields of Tc-99m, and quality control showed that a product with high radionuclidic and radiochemical purity could be obtained. Irradiated natural molybdenum products showed more impurities (Nb-91m, Nb-92m, Nb-95m and Nb-95) than enriched target material. Linear accelerator technology is feasible for production of quality Mo-99/Tc-99m, particularly when paired with Mo-100-enriched targets.

引用

页码：79 / 85

页数：7

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