Phase 1/2, multicenter, non-randomized, open-label, multiple-dose first-in-human study of U3-1402 (anti-HER3 antibody drug conjugate) in subjects with HER3-positive metastatic breast cancer

被引:4
|
作者
Kogawa, Takahiro
Yonemori, Kan
Naito, Yoichi
Noguchi, Emi
Shimizu, Chikako
Tamura, Kenji
Hosono, Ako
Matsubara, Nobuaki
Sugihara, Masahiro
Ogawa, Hayao
Majima, Shuji
Yu, Channing
Ueno, Suguru
Takano, Toshimi
机构
关键词
D O I
10.1200/JCO.2017.35.15_suppl.TPS1116
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
TPS1116
引用
收藏
页数:5
相关论文
共 50 条
  • [41] Interim results from the first open-label, multicenter, phase IIIb study investigating the combination of pertuzumab with subcutaneous trastuzumab and a taxane in patients with HER2-positive metastatic breast cancer (SAPPHIRE)
    Woodward, N.
    De Boer, R. H.
    Redfern, A.
    White, M.
    Young, J.
    Truman, M.
    Beith, J.
    CANCER RESEARCH, 2016, 76
  • [42] Phase 1 study of new formulation of patritumab (U3-1287) Process 2, a fully human anti-HER3 monoclonal antibody in combination with erlotinib in Japanese patients with advanced non-small cell lung cancer
    Toshio Shimizu
    Kimio Yonesaka
    Hidetoshi Hayashi
    Tsutomu Iwasa
    Koji Haratani
    Hironori Yamada
    Shoichi Ohwada
    Emi Kamiyama
    Kazuhiko Nakagawa
    Cancer Chemotherapy and Pharmacology, 2017, 79 : 489 - 495
  • [43] BL-B01D1, a first-in-class EGFR-HER3 bispecific antibody- drug conjugate, in patients with locally advanced or metastatic solid tumours: afirst-in-human, open-label, multicentre, phase 1 study
    Ma, Yuxiang
    Huang, Yan
    Zhao, Yuanyuan
    Zhao, Shen
    Xue, Jinhui
    Yang, Yunpeng
    Fang, Wenfeng
    Guo, Ye
    Han, Yaqian
    Yang, Kunyu
    Li, Yongsheng
    Yang, Jun
    Fu, Zhenming
    Chen, Gang
    Chen, Likun
    Zhou, Ningning
    Zhou, Ting
    Zhang, Yaxiong
    Zhou, Huaqiang
    Liu, Qianwen
    Zhu, Yi
    Zhu, Hai
    Xiao, Sa
    Zhang, Li
    Zhao, Hongyun
    LANCET ONCOLOGY, 2024, 25 (07): : 901 - 911
  • [44] Phase I, first-in-human, open-label, dose-escalation study of U3-1565, a fully human anti-HB-EGF monoclonal antibody, in patients with advanced solid tumors.
    Moore, Kathleen N.
    Bendell, Johanna C.
    Olszanski, Anthony J.
    Desai, Madhuri
    Jansen, Mendel
    Scheyer, Richard David
    Senaldi, Giorgio
    LoRusso, Patricia
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (15)
  • [45] BL-M07D1, an antibody- drug conjugate directed to HER2 in patients with locally advanced or metastatic Breast Cancer with HER2-positive/low-expression and other solid tumors: Results from a first-in-human phase 1 study
    Song, Erwei
    Yao, Herui
    Sun, Meili
    Zong, Hong
    Lin, Rongbo
    Zou, Wen
    Ding, Muran
    Yu, Jing
    Xiao, Sa
    Wang, Hongwei
    Zhu, Hai
    Olivo, Martin
    Zhu, Yi
    CANCER RESEARCH, 2024, 84 (09)
  • [46] A multiple center, open-label, single-arm, phase II clinical trial of MRG002, an HER2-targeted antibody-drug conjugate, in patients with HER2-low expressing advanced or metastatic breast cancer.
    Jiang, Zefei
    Sun, Tao
    Wang, Xiaojia
    Liu, Qiang
    Yan, Min
    Tong, Zhongsheng
    Geng, Cuizhi
    Tang, Jinhai
    Yin, Yongmei
    Yu, Guohua
    Wang, Jingfen
    Su, Wuyun
    Wang, Shusen
    Pan, Yueyin
    Yang, Hua
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [47] A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive, heavily pretreated solid tumors: Results from a phase Ia/Ib, first-in-human, open-label, single-center study.
    Song, Na
    Teng, Yuee
    Teng, Zan
    Shi, Jing
    Jin, Bo
    Qu, Jinglei
    Zhang, Lingyun
    Yu, Ping
    Zhao, Lei
    Wang, Jin
    Li, Aodi
    Tong, Linlin
    Liu, Yunpeng
    Qu, Xiujuan
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [48] Subgroup analysis of patients with HER2-negative metastatic breast cancer in the second-line setting from a phase 3, open-label, randomized study of eribulin mesilate versus capecitabine
    Pivot, Xavier
    Im, Seock Ah
    Guo, Matthew
    Marme, Frederik
    BREAST CANCER, 2018, 25 (03) : 370 - 374
  • [49] Subgroup analysis of patients with HER2-negative metastatic breast cancer in the second-line setting from a phase 3, open-label, randomized study of eribulin mesilate versus capecitabine
    Xavier Pivot
    Seock Ah Im
    Matthew Guo
    Frederik Marmé
    Breast Cancer, 2018, 25 : 370 - 374
  • [50] Updated safety results from the first multicenter, open-label, phase IIIb study investigating the combination of pertuzumab with subcutaneous trastuzumab and a taxane in patients with HER2-positive metastatic breast cancer (SAPPHIRE)
    Woodward, N.
    De Boer, R. H.
    Redfern, A.
    White, M.
    Roberts, W.
    Truman, M.
    Beith, J.
    CANCER RESEARCH, 2017, 77