Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

被引：13

作者：

Takahashi, T ^{[1
]}

Tanaka, H ^{[1
]}

Matsuda, A ^{[1
]}

Doi, T ^{[1
]}

Yamada, H ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Chem Engn, Meguro Ku, Tokyo 1528552, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(98)00605-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses of hybrid DNA cleaving molecules which have the 9-membered enediyne structure of kedarcidin with the DNA intercalator of NCS and/or the sugar moieties were accomplished. Introduction of the sugar moieties to the masked enediyne was achieved via S-alkylation of a bromoacetate derivative with a sugar-containing thiol without the need for protection of the sugar moiety. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3299 / 3302

页数：4

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