Genotoxicity of Two Nanoparticles: Titanium Dioxide and Zinc Oxide

被引：8
|
作者：
Unal, Fatma [1 ]
Demirtas Korkmaz, Funda [1 ]
Suludere, Zekiye [1 ]
Erol, Ozlem [2 ]
Yuzbasioglu, Deniz [1 ]
机构：
[1] Gazi Univ, Sci Fac, Dept Biol, TR-06560 Ankara, Turkey
[2] Gazi Univ, Sci Fac, Dept Chem, TR-06560 Ankara, Turkey
来源：
GAZI UNIVERSITY JOURNAL OF SCIENCE | 2021年 / 34卷 / 04期
关键词：
Titanium dioxide nanoparticles; Zinc oxide nanoparticles; Chromosome aberration test; Micronucleus test; Comet assay; IN-VITRO; COMET ASSAY; DNA-DAMAGE; BLOOD; MECHANISMS; VIVO; LYMPHOCYTES; PARTICLES; INDUCTION; EXPOSURE;
D O I：
10.35378/gujs.826911
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nanoparticles (NPs) and nanoparticle-based materials have been increasingly used in various consumer and medical applications. However, investigations have disclosed that some NPs may generate toxic effects in different cell types and organisms. In this study, the cytotoxic and genotoxic potential of titanium dioxide (TiO2) and zinc oxide (ZnO) NPs were examined by using four genotoxicity tests, chromosome aberrations-CAs, sister chromatid exchange-SCE, micronucleus-MN, and comet, in human lymphocytes in vitro. The results showed that both NPs significantly increased the frequency of aberrant cells, CA/Cell, SCE, and DNA damage, and decreased mitotic index in some treatments. These results demonstrated that TiO2 and ZnO NPs induce genotoxic effects. Therefore, more detailed in vitro and in vivo experiments should be conducted for the safe usage of both NPs.
引用
收藏
页码：948 / 958
页数：11
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