Lifetime fluorescence apparatus for clinical investigations of tissues

被引：0
|
作者：
Marcu, L [1 ]
Fang, QY [1 ]
Papaioannou, T [1 ]
Jo, JA [1 ]
Vaitha, R [1 ]
Shastry, K [1 ]
机构：
[1] Cedars Sinai Med Ctr, Dept Surg, MISTI, Los Angeles, CA 90048 USA
来源：
DIAGNOSTIC OPTICAL SPECTROSCOPY IN BIOMEDICINE II | 2003年 / 5141卷
关键词：
time-resolved fluorescence spectroscopy; intraoperative diagnostics; arterial diseases; fiberoptic probes;
D O I：
10.1117/12.501020
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
We report on the design, development, and performance of a versatile and mobile fiber-optic based time-resolved fluorescence apparatus for in-vivo spectroscopy of biological tissues. The apparatus is of modular design which allows for facile interfacing with different pulsed light sources and fiber-optic probes. Main features of the apparatus include: 1) fast acquisition of fluorescence decays with high temporal resolution (0.3 ns) for a broad range of emission wavelengths (300 to 850 nm) and lifetimes (0.3 ns to ins), 2) near real time analysis of fluorescence decays via a Laguerre deconvolution technique, and 3) compatibility with the clinical environment (endoscopic procedures or other intraoperative uses). The apparatus is currently employed for in-vivo studies of diseased tissues (cardiovascular and oncological applications).
引用
收藏
页码：40 / 46
页数：7
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