A novel dual-site ICT/AIE fluorescent probe for detecting hypochlorite and polarity in living cells

被引：15
|
作者：
Li, Mingrui [1 ]
Fang, Wangwang [2 ]
Wang, Bowei [1 ,3 ,4 ]
Du, Yuchao [1 ]
Hou, Yuqing [5 ]
Chen, Ligong [1 ,3 ,4 ]
Cui, Siqian [1 ]
Li, Yang [1 ,3 ]
Yan, Xilong [1 ,3 ,4 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China
[2] Shaoxing Xingxin New Mat Co Ltd, Shangyu City 312369, Zhejiang, Peoples R China
[3] Tianjin Engn Res Ctr Funct Fine Chem, Tianjin, Peoples R China
[4] Tianjin Univ, Zhejiang Shaoxing Inst, Shaoxing, Zhejiang, Peoples R China
[5] Zhejiang Lonsen Grp Co Ltd, Shaoxing 312300, Zhejiang, Peoples R China
来源：
NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 45期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
AGGREGATION-INDUCED EMISSION; MYELOPEROXIDASE; HCLO; ACID; SELECTIVITY; OXIDATION; CRUMBS; MODEL; DOTS; DYES;
D O I：
10.1039/d1nj03558d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel dual-site fluorescent probe (CTPA) was rationally designed and synthesized for the detection of hypochlorite (ClO-) and polarity. CTPA displayed an excellent sensitivity (LOD = 11.9 nM) and selectivity as well as a rapid response within 30 s to ClO-. Besides, it is worth noting that the introduction of triphenylamine into the D-pi-A structure is beneficial to monitor the fluctuation of polarity. It was found that CTPA could respond to polarity fluctuation via the two channels of fluorescence intensity and maximum emission wavelength. In addition, CTPA exhibited low toxicity and was successfully applied to detect the endogenous and exogenous ClO- in HeLa cells and HIN-3T3 cells and distinguish the two kinds of cells by ClO- and polarity. Furthermore, this work provides a promising strategy for the development of dual-site fluorescent probes aiming at the detection of biologically relevant analytes by the collocation of recognizing groups.
引用
收藏
页码：21406 / 21414
页数：9
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